Enormous progress in mapping complex traits in humans has been made in the last 5 yr.
There has been early success for prevalent diseases with complex phenotypes. These …

Personalized medicine is a broad and rapidly advancing field of health care that is informed
by each person's unique clinical, genetic, genomic, and environmental information …

Abstract NONCODE (http://www. bioinfo. org/noncode/) is a systematic database that is
dedicated to presenting the most complete collection and annotation of non-coding RNAs …

More than 100 distinct chemical modifications to RNA have been characterized so far.
However, the prevalence, mechanisms and functions of various RNA modifications remain …

Distinguishing the few disease-related variants from a massive number of passenger
variants is a major challenge. Variants affecting RNA modifications that play critical roles in …

With recent progress in mapping N7-methylguanosine (m7G) RNA methylation sites, tens of
thousands of experimentally validated m7G sites have been discovered in various species …

Background Mapping of orthologous genes among species serves an important role in
functional genomics by allowing researchers to develop hypotheses about gene function in …

The search for the alleles that matter, the quantitative trait nucleotides (QTNs) that underlie
heritable variation within populations and divergence among them, is a popular pursuit. But …

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic
studies have identified common CKD susceptibility variants. The CKDGen consortium …

Equivalence testing has grown significantly in importance over the last two decades,
especially as its relevance to a variety of applications has become understood. Yet …