Positive allosteric modulators (PAMs) of G protein-coupled receptors (GPCRs) have drawn
attention as novel drug candidates. PAMs can enhance the activities of endogenous …

Stapled peptides are an emerging class of drugs with a unique set of properties that fully
capitalize on 25 years of genetic research to attack drivers of complex diseases, including …

Bridged peptides including stapled peptides are attractive tools for regulating protein–
protein interactions (PPIs). An effective synthetic methodology in a heterogeneous system …

To date, several anti-human immunodeficiency virus (HIV) drugs such as reverse
transcriptase inhibitors, protease inhibitors and integrase inhibitors have been developed …

Three types of stabilized helical peptides containing disulfide bonds, C–C cross-linked side
chains, or α, α-disubstituted amino acids (2-aminoisobutyric acid (Aib)) were designed and …

Peptide inhibitors with cell permeability targeting an HIV‐1 capsid (CA) protein might make
therapeutic by regulating HIV‐1 replication. Overlapping fragment peptide libraries covering …

Anomalous protein-protein interactions (PPIs) have been correlated to a variety of disease
states, such as cancer, infectious disease, neurological disorders, diabetes, endocrine …

We designed and synthesized two dodecapeptides, Boc-(l-Leu-l-Leu-Aib-d-Leu-d-Leu-Aib)
2-OMe (5) and Boc-l-Leu-l-Leu-Aib-(d-Leu-d-Leu-Aib) 2-l-Leu-l-Leu-Aib-OMe (6), that …

The basic DNA recognition region of the GCN4 protein comprising 23 amino acids has been
modified to contain two optimally positioned cysteines which have been linked and stapled …

Ethynylpyridine polymers and oligomers consisting of 4‐substituted pyridine rings linked by
acetylene bonds at the 2‐and 6‐positions have been investigated. Ethynylpyridine …