We are exploring constraining aromatic residues in the kappa opioid receptor selective
antagonist arodyn (Ac [Phe1, 2, 3, Arg4, d-Ala8] dynorphin A (1-11)-NH2) by ring closing …

Previously, compounds which inhibit the HIV-1 replication cycle were found in overlapping
peptide libraries covering the whole sequence of an HIV-1 matrix (MA) protein constructed …

Several anti-HIV-1 peptides have previously been found among overlapping fragment
peptide libraries that contain an octa-arginyl moiety and cover the whole sequence of an HIV …

From library screening of synthetic antimicrobial peptides, an O-allyltyrosine-based
tripeptide was identified to possess inhibitory activity against HIV-1 integrase (IN) exhibiting …

Drug resistance poses a significant threat to ongoing malaria control efforts. Coupled with
lack of a malaria vaccine, there is an urgent need for the development of new antimalarials …

The capsid of human immunodeficiency virus type 1 (HIV-1) forms a conical structure by
assembling oligomers of capsid (CA) proteins and is a virion shell that encapsulates viral …

Hybrid molecules containing small CD4 mimics and gp41-C-terminal heptad repeat (CHR)-
related peptides have been developed. A YIR-821 derivative was adopted as a CD4 mimic …

Steroids are important components of cell membranes and are involved in several
physiological functions. A diphenylmethane (DPM) skeleton has recently been suggested to …

Ring-closing metathesis is commonly utilized in peptide macro-cyclization. The influence of
α-methylation of the amino acids bearing the olefin moieties has never been systematically …

''Inflammation''broadly describes a tissue response to insult. It may be pathological, or it may
be healthy and regenerative. 1 Therapeutic approaches to inflammation have tended to …