Lengthy peptides corresponding to the C-terminal heptad repeat (C-peptides) of human
immunodeficiency virus type 1 (HIV-1) gp41 are potent inhibitors against virus–cell fusion …

The most abundant protein secondary structure in nature–the α-helix–is frequently found at
protein interfaces, making it an important lead structure for the design of small-molecule …

Membrane fusion is a valid target for inhibition of HIV-1 replication. A 34-mer fragment
peptide (C34), which is contained in the HIV-1 envelope protein gp41, has significant anti …

A nonameric (pyridine–acetylene–phenol–acetylene) 4–pyridine oligomer formed a helical
structure by intermolecular templation with a hexose such as d‐glucose associated by the …

Macrocyclization of peptides has inspired both basic research and drug discovery focused
on Nature's three dimensional (3D) molecular recognition underlying intracellular protein …

HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS
therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common …

Vitamin D receptor (VDR) is a family of nuclear receptors (NR) that regulates physiological
effects such as the immune system, calcium homeostasis, and cell proliferation. We …

The ubiquity and variety of protein-protein interactions (PPI) mediating the human protein
interactome make them an attractive yet daunting target for investigation and therapeutic …

The capsid of human immunodeficiency virus type 1 (HIV-1) is a shell that encloses viral
RNA and is highly conserved among many strains of the virus. It forms a conical structure by …

Integrins are ubiquitously expressed cell-adhesion proteins. Activation of integrins is
triggered by talin through an inside-out signaling pathway, which can be driven by RAP1 …