Materials for oral delivery of proteins and peptides

TD Brown, KA Whitehead, S Mitragotri - Nature Reviews Materials, 2020 - nature.com
Throughout history, oral administration has been regarded as the most convenient mode of
drug delivery, as it requires minimal expertise and invasiveness. Although oral delivery …

Oral drug delivery platforms for biomedical applications

J Ouyang, Z Zhang, B Deng, J Liu, L Wang, H Liu… - Materials Today, 2023 - Elsevier
Oral administration is perhaps the most commonly used and acceptable route for drug
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …

Chitosan and its derivatives for application in mucoadhesive drug delivery systems

TM M. Ways, WM Lau, VV Khutoryanskiy - Polymers, 2018 - mdpi.com
Mucoadhesive drug delivery systems are desirable as they can increase the residence time
of drugs at the site of absorption/action, provide sustained drug release and minimize the …

Surface modification of lipid-based nanoparticles

Y Xu, T Fourniols, Y Labrak, V Préat, A Beloqui… - ACS …, 2022 - ACS Publications
There is a growing interest in the development of lipid-based nanocarriers for multiple
purposes, including the recent increase of these nanocarriers as vaccine components …

Gold nanoparticles (GNPs) in biomedical and clinical applications: A review

MI Anik, N Mahmud, A Al Masud, M Hasan - Nano Select, 2022 - Wiley Online Library
Gold nanoparticles (GNPs) have been extensively used in various applications ranging from
environmental detection to biomedical applications. Due to their unique characteristics such …

[HTML][HTML] Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

P Lundquist, P Artursson - Advanced drug delivery reviews, 2016 - Elsevier
In this contribution, we review the molecular and physiological barriers to oral delivery of
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …

Stimulus-cleavable chemistry in the field of controlled drug delivery

Y Xue, H Bai, B Peng, B Fang, J Baell, L Li… - Chemical Society …, 2021 - pubs.rsc.org
Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

Role of metals in Alzheimer's disease

N Das, J Raymick, S Sarkar - Metabolic brain disease, 2021 - Springer
Metal homeostasis in the central nervous system (CNS) is a crucial component of healthy
brain function, because metals serve as enzymatic cofactors and are key components of …

Hypromellose–A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery

E Mašková, K Kubová, BT Raimi-Abraham… - Journal of controlled …, 2020 - Elsevier
Hydroxypropylmethylcellulose (HPMC), also known as Hypromellose, is a traditional
pharmaceutical excipient widely exploited in oral sustained drug release matrix systems …

Transporter-guided delivery of nanoparticles to improve drug permeation across cellular barriers and drug exposure to selective cell types

L Kou, YD Bhutia, Q Yao, Z He, J Sun… - Frontiers in …, 2018 - frontiersin.org
Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-
surface receptors or transporters could enhance the efficacy of drug delivery and therapy …