Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer

CCL Tong, J Kao, AG Sikora - Immunologic research, 2012 - Springer
The estimated annual incidence of oral cavity and pharyngeal cancer is 39,000 in the United
States and 260,000 cases worldwide. Despite significant advances in surgery …

Benign SNPs in the Coding Region of TP53: Finding the Needles in a Haystack of Pathogenic Variants

T Soussi - Cancer Research, 2022 - AACR
With the recent explosion in high-throughput genotyping technology, the amount and quality
of SNP data have increased exponentially, facilitating the discovery of multiple uncommon …

In vitro and in vivo anti-tumor activity of Coenzyme Q0 against TWIST1-overexpressing HNSCC cells: ROS-mediated inhibition of EMT/metastasis and autophagy …

HL Yang, LW Chiu, YA Lin, S Pandey… - Toxicology and Applied …, 2023 - Elsevier
Abstract HNSCC (Head and Heck Squamous Cell Carcinoma) is a reasonably prevalent
cancer with a high mortality rate. In this study, we tried to examine the anti-metastasis and …

[HTML][HTML] Development and validation of an autophagy-related LncRNA prognostic signature in head and neck squamous cell carcinoma

L Shen, N Li, Q Zhou, Z Li, L Shen - Frontiers in Oncology, 2021 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is one of the greatest public challenges
because of delayed diagnosis and poor prognosis. In this study, we established an …

Is fibroblast growth factor receptor 4 a suitable target of cancer therapy?

C Heinzle, Z Erdem, J Paur… - Current …, 2014 - ingentaconnect.com
Fibroblast growth factors (FGF) and their tyrosine kinase receptors (FGFR) support cell
proliferation, survival and migration during embryonic development, organogenesis and …

MART-10, a novel vitamin D analog, inhibits head and neck squamous carcinoma cells growth through cell cycle arrest at G0/G1 with upregulation of p21 and p27 and …

KC Chiang, CN Yeh, JT Hsu, LW Chen, SF Kuo… - The Journal of Steroid …, 2013 - Elsevier
For the head and neck squamous cell carcinoma (HNSCC), surgery in combination with
radiation therapy is the current standard treatment. However, the complex anatomy and …

[HTML][HTML] DNA double-strand break response and repair gene polymorphisms may influence therapy results and prognosis in head and neck cancer patients

D Butkiewicz, M Krześniak, A Gdowicz-Kłosok… - Cancers, 2023 - mdpi.com
Simple Summary Head and neck cancer (HNC) is characterized by radio-and
chemoresistance contributing to treatment failure and poor prognosis. There is evidence that …

[HTML][HTML] Fibroblast growth factor receptor family members as prognostic biomarkers in head and neck squamous cell carcinoma: a systematic review

NA Ipenburg, K Koole, KS Liem, PMW van Kempen… - Targeted …, 2016 - Springer
Background Since head and neck cancer is characterized by poor survival rates, there is a
demand for novel therapeutic targets and prognostic biomarkers. An upcoming therapeutic …

The association between the XRCC1 Arg399Gln polymorphism and the risk of head and neck cancer: an updated meta-analysis including 14586 subjects

S Xia, S Wu, M Wang - Technology in cancer research & …, 2021 - journals.sagepub.com
Background: Accumulated evidence shows that DNA repair gene X-ray repair cross
complementing group 1 (XRCC1) may determine individual susceptibility to head and neck …

FGFR4 is a potential predictive biomarker in oral and oropharyngeal squamous cell carcinoma

K Koole, PMW Van Kempen, LW Van Bockel, T Smets… - Pathobiology, 2015 - karger.com
Objective: The aim of this study was to investigate whether fibroblast growth factor receptor 4
(FGFR4) could serve as a potential therapeutic target, prognostic biomarker or biomarker …