Acetylcholine beyond neurons: the non‐neuronal cholinergic system in humans

I Wessler, CJ Kirkpatrick - British journal of pharmacology, 2008 - Wiley Online Library
Animal life is controlled by neurons and in this setting cholinergic neurons play an important
role. Cholinergic neurons release ACh, which via nicotinic and muscarinic receptors (n‐and …

Choline transport for phospholipid synthesis

V Michel, Z Yuan, S Ramsubir… - … biology and medicine, 2006 - journals.sagepub.com
Choline is an essential nutrient for all cells because it plays a role in the synthesis of the
membrane phospholipid components of the cell membranes, as a methyl-group donor in …

Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium

KS Lips, C Volk, BM Schmitt, U Pfeil… - American journal of …, 2005 - atsjournals.org
In airway epithelia, non-neuronal cholinergic regulations have been described; however, the
route for acetylcholine (ACh) release has not been verified. To investigate whether organic …

The epithelial cholinergic system of the airways

W Kummer, KS Lips, U Pfeil - Histochemistry and cell biology, 2008 - Springer
Acetylcholine (ACh), a classical transmitter of parasympathetic nerve fibres in the airways, is
also synthesized by a large number of non-neuronal cells, including airway surface …

Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells

BJ Proskocil, HS Sekhon, Y Jia, V Savchenko… - …, 2004 - academic.oup.com
The role of acetylcholine (ACh) as a key neurotransmitter in the central and peripheral
nervous system is well established. However, the role of ACh may be broader because ACh …

Basic and clinical aspects of non-neuronal acetylcholine: overview of non-neuronal cholinergic systems and their biological

SK Kawashima, T Fujii - Journal of pharmacological sciences, 2008 - Elsevier
Acetylcholine (ACh) is a phylogenetically ancient molecule involved in cell-to-cell signaling
in almost all life-forms on earth. Cholinergic components, including ACh, choline …

Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract

B Schütz, I Jurastow, S Bader, C Ringer… - Frontiers in …, 2015 - frontiersin.org
The mouse gastro-intestinal and biliary tract mucosal epithelia harbor choline
acetyltransferase (ChAT)-positive brush cells with taste cell-like traits. With the aid of two …

The non-neuronal cholinergic system in the airways: an unappreciated regulatory role in pulmonary inflammation?

CR Gwilt, LE Donnelly, DF Rogers - Pharmacology & therapeutics, 2007 - Elsevier
The parasympathetic neurotransmitter acetylcholine is also synthesised and secreted by
non-neuronal cells and modifies their behaviour. This is termed the “non-neuronal …

Functional expression of choline transporters in the blood–brain barrier

M Inazu - Nutrients, 2019 - mdpi.com
Cholinergic neurons in the central nervous system play a vital role in higher brain functions,
such as learning and memory. Choline is essential for the synthesis of the neurotransmitter …

Control by cholinergic mechanisms

K Racké, UR Juergens, S Matthiesen - European journal of pharmacology, 2006 - Elsevier
In the respiratory tract acetylcholine is neurotransmitter in ganglia and postganglionic
parasympathetic nerves, but in addition is paracrine mediator released from various non …