Kidney damage varies according to the primary insult. Different aetiologies of acute kidney
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …

Perivascular niches in the kidney comprise heterogeneous cell populations, including
pericytes and fibroblasts, with distinct functions. These perivascular cells have crucial roles …

Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …

Sepsis-associated AKI is a life-threatening complication that is associated with high
morbidity and mortality in patients who are critically ill. Although it is clear early supportive …

Acute kidney injury is common, with~ 13 million cases and 1.7 million deaths/year
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …

Besides the excretion of metabolic wastes, the kidneys regulate the balance of 32
electrolytes, acid-base, and blood pressure (12, 23). Sex differences in renal function 33 and …

The kidneys receive approximately 20% of cardiac output and have a low fractional oxygen
extraction. Quite paradoxically, however, the kidneys are highly susceptible to ischemic …

Normothermic machine perfusion (NMP) has emerged as a promising tool for the
preservation, viability assessment, and repair of deceased-donor kidneys prior to …

Red blood cell (RBC) trapping is common in ischemic acute kidney injury (AKI) and presents
as densely packed RBCs that accumulate within and engorge the kidney medullary …

Background Vascular congestion of the renal medulla—trapped red blood cells in the
medullary microvasculature—is a hallmark finding at autopsy in patients with ischemic acute …