Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection
H Scholz, FJ Boivin, KM Schmidt-Ott… - Nature Reviews …, 2021 - nature.com
Kidney damage varies according to the primary insult. Different aetiologies of acute kidney
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …
Role of perivascular cells in kidney homeostasis, inflammation, repair and fibrosis
S Tanaka, D Portilla, MD Okusa - Nature Reviews Nephrology, 2023 - nature.com
Perivascular niches in the kidney comprise heterogeneous cell populations, including
pericytes and fibroblasts, with distinct functions. These perivascular cells have crucial roles …
pericytes and fibroblasts, with distinct functions. These perivascular cells have crucial roles …
Matters of the heart: cellular sex differences
Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …
The pathophysiology of sepsis-associated AKI
S Kuwabara, E Goggins, MD Okusa - Clinical Journal of the …, 2022 - journals.lww.com
Sepsis-associated AKI is a life-threatening complication that is associated with high
morbidity and mortality in patients who are critically ill. Although it is clear early supportive …
morbidity and mortality in patients who are critically ill. Although it is clear early supportive …
Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia
F Freitas, D Attwell - Elife, 2022 - elifesciences.org
Acute kidney injury is common, with~ 13 million cases and 1.7 million deaths/year
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …
Recent advances in sex differences in kidney function
AT Layton, JC Sullivan - American Journal of Physiology …, 2019 - journals.physiology.org
Besides the excretion of metabolic wastes, the kidneys regulate the balance of 32
electrolytes, acid-base, and blood pressure (12, 23). Sex differences in renal function 33 and …
electrolytes, acid-base, and blood pressure (12, 23). Sex differences in renal function 33 and …
Ischemic renal injury: can renal anatomy and associated vascular congestion explain why the medulla and not the cortex is where the trouble starts?
SC Ray, J Mason, PM O'Connor - Seminars in nephrology, 2019 - Elsevier
The kidneys receive approximately 20% of cardiac output and have a low fractional oxygen
extraction. Quite paradoxically, however, the kidneys are highly susceptible to ischemic …
extraction. Quite paradoxically, however, the kidneys are highly susceptible to ischemic …
[HTML][HTML] Utilizing pathophysiological concepts of ischemia-reperfusion injury to design renoprotective strategies and therapeutic interventions for normothermic ex vivo …
B Ogurlu, TL Hamelink, IM Van Tricht… - American Journal of …, 2024 - Elsevier
Normothermic machine perfusion (NMP) has emerged as a promising tool for the
preservation, viability assessment, and repair of deceased-donor kidneys prior to …
preservation, viability assessment, and repair of deceased-donor kidneys prior to …
Extravasation of blood and blood toxicity drives tubular injury from RBC trapping in ischemic AKI
Red blood cell (RBC) trapping is common in ischemic acute kidney injury (AKI) and presents
as densely packed RBCs that accumulate within and engorge the kidney medullary …
as densely packed RBCs that accumulate within and engorge the kidney medullary …
Lipopolysaccharide pretreatment prevents medullary vascular congestion following renal ischemia by limiting early reperfusion of the medullary circulation
SR McLarnon, K Wilson, B Patel, J Sun… - Journal of the …, 2022 - journals.lww.com
Background Vascular congestion of the renal medulla—trapped red blood cells in the
medullary microvasculature—is a hallmark finding at autopsy in patients with ischemic acute …
medullary microvasculature—is a hallmark finding at autopsy in patients with ischemic acute …