Insights from Mendelian randomization and genetic correlation analyses into the relationship between endometriosis and its comorbidities

IM McGrath, GW Montgomery… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Endometriosis remains a poorly understood disease, despite its high
prevalence and debilitating symptoms. The overlap in symptoms and the increased risk of …

Omics-based novel strategies in the diagnosis of endometriosis

M Samare-Najaf, SA Razavinasab… - Critical Reviews in …, 2024 - Taylor & Francis
Endometriosis, an enigmatic and chronic disorder, is considered a debilitating condition
despite being benign. Globally, this gynecologic disorder affects up to 10% of females of …

New concepts on the etiology of endometriosis

FL Cousins, BD McKinnon, S Mortlock… - Journal of Obstetrics …, 2023 - Wiley Online Library
Endometriosis is a serious, chronic disorder where endometrial tissue grows outside the
uterus, causing severe pelvic pain and infertility. It affects 11% of women. Endometriosis is a …

Genomic characterisation of the overlap of endometriosis with 76 comorbidities identifies pleiotropic and causal mechanisms underlying disease risk

IM McGrath… - Human Genetics, 2023 - Springer
Comorbid conditions can be driven by underlying pleiotropic and causal mechanisms that
can provide insights into shared molecular and biological processes contributing to disease …

Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone

IM McGrath… - BMC medicine, 2023 - Springer
Background Endometriosis affects 1 in 9 women, yet it is poorly understood with long
diagnostic delays, invasive diagnoses, and poor treatment outcomes. Characterised by the …

Endometriosis-associated ovarian cancer: what are the implications for women with intact endometrioma planning for a future pregnancy? A reproductive clinical …

JS Younis - Biomolecules, 2022 - mdpi.com
Endometriosis is a chronic, universal, and prevalent disease estimated to affect up to 1: 10
women of reproductive age. Endometriosis-associated ovarian cancer (EAOC) developing …

IGF2BP2 promotes the progression of ovarian endometriosis by regulating m6A-modified MEIS2 and GATA6

S Zhao, B Zhang, H Yuan, Y Yin, S Qi, W Li… - … International Journal of …, 2022 - Elsevier
Background m6A-RNA modification mediated by the N6-methyladenosine RNA methylation-
related molecule methyltransferase-like 3 has been implicated in the progression of …

Endometriosis-related ovarian cancers: evidence for a dichotomy in the histogenesis of the two associated histotypes

A Bergamini, G Mangili, A Ambrosi, G Taccagni… - Diagnostics, 2023 - mdpi.com
Evidence indicates that different pathways of malignant degeneration underlie the
development of endometriosis-associated ovarian tumors of endometrioid and clear cell …

Hot spots and trends in the relationship between cancer and obesity: a systematic review and knowledge graph analysis

L Gao, T Yang, Z Xue, CKD Chan - Life, 2023 - mdpi.com
Cancer is one of the most difficult medical problems in today's world. There are many factors
that induce cancer in humans, and obesity has become an important factor in inducing …

Whole-exome sequencing reveals candidate high-risk susceptibility genes for endometriosis

S Nousiainen, O Kuismin, S Reinikka, R Manninen… - Human Genomics, 2023 - Springer
Background Endometriosis is a common, chronic disease among fertile-aged women.
Disease course may be highly invasive, requiring extensive surgery. The etiology of …