The future of rodent models in depression research
Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …
burden of this debilitating disorder is anticipated to increase markedly over the coming …
Differential impact of stress and environmental enrichment on corticolimbic circuits
Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …
Resource choice during ontogeny enhances both the short-and longer-term welfare of laying hen pullets
RV Holt, L Skånberg, LJ Keeling, I Estevez… - Scientific Reports, 2024 - nature.com
We hypothesised that resource choice during early life contributes to both current and longer-
term beneficial effects on animal welfare. We investigated this hypothesis in a longitudinal …
term beneficial effects on animal welfare. We investigated this hypothesis in a longitudinal …
The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice
Gestational stress can increase postpartum depression in women. To treat maternal
depression, fluoxetine (FLX) is most commonly prescribed. While FLX may be effective for …
depression, fluoxetine (FLX) is most commonly prescribed. While FLX may be effective for …
[HTML][HTML] Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype
AM O'Connor, MH Hagenauer, LCT Forrester… - Neurobiology of …, 2024 - Elsevier
Stress is a major influence on mental health status; the ways that individuals respond to or
copes with stressors determine whether they are negatively affected in the future. Stress …
copes with stressors determine whether they are negatively affected in the future. Stress …
[HTML][HTML] Early life environment and adult enrichment: Effects on fearfulness in laying hens
L Dumontier, AM Janczak, TV Smulders… - Applied Animal …, 2022 - Elsevier
The environmental complexity, both during early and adult life, contributes to shaping
individuals' fearfulness. The present study aimed at testing whether hens reared in an aviary …
individuals' fearfulness. The present study aimed at testing whether hens reared in an aviary …
Environmental influences on placental programming and offspring outcomes following maternal immune activation
KJN Estevez, AN Rondón-Ortiz, JQT Nguyen… - Brain, behavior, and …, 2020 - Elsevier
Adverse experiences during pregnancy induce placental programming, affecting the fetus
and its developmental trajectory. However, the influence of 'positive'maternal experiences …
and its developmental trajectory. However, the influence of 'positive'maternal experiences …
Environmental enrichment prevents stress-induced epigenetic changes in the expression of glucocorticoid receptor and corticotrophin releasing hormone in the …
A Orock, T Louwies, CO Ligon, E Mohammadi… - Experimental …, 2021 - Elsevier
Introduction Stress is a known trigger for the symptoms of irritable bowel syndrome (IBS), a
gastrointestinal (GI) disorder that presents with abnormal bowel habits and abdominal pain …
gastrointestinal (GI) disorder that presents with abnormal bowel habits and abdominal pain …
Hidden talents: Poly (I: C)‐induced maternal immune activation improves mouse visual discrimination performance and reversal learning in a sex‐dependent manner
While there is a strong focus on the negative consequences of maternal immune activation
(MIA) on developing brains, very little attention is directed towards potential advantages of …
(MIA) on developing brains, very little attention is directed towards potential advantages of …
Molecular neurobiology of loss: a role for basolateral amygdala extracellular matrix
Psychological loss is a common experience that erodes well-being and negatively impacts
quality of life. The molecular underpinnings of loss are poorly understood. Here, we …
quality of life. The molecular underpinnings of loss are poorly understood. Here, we …