The future of rodent models in depression research

A Gururajan, A Reif, JF Cryan, DA Slattery - Nature Reviews …, 2019 - nature.com
Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …

Differential impact of stress and environmental enrichment on corticolimbic circuits

MA Smail, BL Smith, N Nawreen, JP Herman - … biochemistry and behavior, 2020 - Elsevier
Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …

Resource choice during ontogeny enhances both the short-and longer-term welfare of laying hen pullets

RV Holt, L Skånberg, LJ Keeling, I Estevez… - Scientific Reports, 2024 - nature.com
We hypothesised that resource choice during early life contributes to both current and longer-
term beneficial effects on animal welfare. We investigated this hypothesis in a longitudinal …

The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice

H Bashiri, DJ Houwing, JR Homberg, AA Salari - Scientific Reports, 2021 - nature.com
Gestational stress can increase postpartum depression in women. To treat maternal
depression, fluoxetine (FLX) is most commonly prescribed. While FLX may be effective for …

[HTML][HTML] Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype

AM O'Connor, MH Hagenauer, LCT Forrester… - Neurobiology of …, 2024 - Elsevier
Stress is a major influence on mental health status; the ways that individuals respond to or
copes with stressors determine whether they are negatively affected in the future. Stress …

[HTML][HTML] Early life environment and adult enrichment: Effects on fearfulness in laying hens

L Dumontier, AM Janczak, TV Smulders… - Applied Animal …, 2022 - Elsevier
The environmental complexity, both during early and adult life, contributes to shaping
individuals' fearfulness. The present study aimed at testing whether hens reared in an aviary …

Environmental influences on placental programming and offspring outcomes following maternal immune activation

KJN Estevez, AN Rondón-Ortiz, JQT Nguyen… - Brain, behavior, and …, 2020 - Elsevier
Adverse experiences during pregnancy induce placental programming, affecting the fetus
and its developmental trajectory. However, the influence of 'positive'maternal experiences …

Environmental enrichment prevents stress-induced epigenetic changes in the expression of glucocorticoid receptor and corticotrophin releasing hormone in the …

A Orock, T Louwies, CO Ligon, E Mohammadi… - Experimental …, 2021 - Elsevier
Introduction Stress is a known trigger for the symptoms of irritable bowel syndrome (IBS), a
gastrointestinal (GI) disorder that presents with abnormal bowel habits and abdominal pain …

Hidden talents: Poly (I: C)‐induced maternal immune activation improves mouse visual discrimination performance and reversal learning in a sex‐dependent manner

X Zhao, H Tran, H DeRosa… - Genes, Brain and …, 2021 - Wiley Online Library
While there is a strong focus on the negative consequences of maternal immune activation
(MIA) on developing brains, very little attention is directed towards potential advantages of …

Molecular neurobiology of loss: a role for basolateral amygdala extracellular matrix

MA Smail, BL Smith, R Shukla, K Alganem… - Molecular …, 2023 - nature.com
Psychological loss is a common experience that erodes well-being and negatively impacts
quality of life. The molecular underpinnings of loss are poorly understood. Here, we …