The central nervous system (CNS), consisting of the brain, spinal cord, and retina,
superintends to the acquisition, integration and processing of peripheral information to …

Among central nervous system tumors, Glioblastoma (GBM) is the most common, aggressive
and neurological destructive primary brain tumor in adults. Standard care therapy for GBM …

Chemotherapy is commonly associated with limited effectiveness and unwanted side effects
in normal cells and tissues, due to the lack of specificity of therapeutic agents to cancer cells …

The local delivery of chemotherapeutic agents is a very promising strategy for the treatment
of glioblastoma (GBM). Gemcitabine is a chemotherapeutic agent that has a different …

Despite the emergence of cutting-edge therapeutic strategies and tremendous progress in
research, a complete cure of glioma remains elusive. The heterogenous nature of tumor …

Malignant gliomas are a type of primary brain tumour that originates in glial cells. Among
them, glioblastoma multiforme (GBM) is the most common and the most aggressive brain …

Despite intensive surgical excision, radiation therapy, and chemotherapy, the current life
expectancy for patients diagnosed with glioblastoma multiforme is only 12 to 15 months …

During cancer genesis, the extracellular matrix (ECM) in the human brain undergoes
important transformations, starting to resemble embryonic brain cell milieu with a much …

Glioblastoma multiforme (GBM) has several distinctive characteristics linked to a poor early-
stage prognosis. The crucial obstacle in the treatment of GBM is the inability of chemo drugs …

Despite recent technological advancements and promising preclinical experiments, brain
tumor patients are still met with limited treatment options. Some of the barriers to clinical …