The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …

Synaptic pathology and mitochondrial oxidative damage are early events in Alzheimer's
disease (AD) progression. Loss of synapses and synaptic damage are the best correlates of …

The negative impact of obesity on reproductive success is well documented but the stages at
which development of the conceptus is compromised and the mechanisms responsible for …

BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

Oocyte maturation is a long process during which oocytes acquire their intrinsic ability to
support the subsequent stages of development in a stepwise manner, ultimately reaching …

Sex differences in human health and disease can range from undetectable to profound.
Differences in brain tumor rates and outcome are evident in males and females throughout …

The role of metabolism in ovarian aging is poorly described, despite the fact that ovaries fail
earlier than most other organs. Growing interest in ovarian function is being driven by recent …

Mitochondria are key cytoplasmic organelles, responsible for generating cellular energy,
regulating intracellular calcium levels, altering the reduction-oxidation potential of cells, and …

Optimal maturation of the oocyte depends on its environment and determines embryo
competence, because the embryonic genome is not active until the cleavage stage and new …

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization
(IVF). In the past decade, extensive observations demonstrated that the mitochondrion plays …