Visualization of the cellular heterogeneity and spatial architecture of the tumor
microenvironment (TME) is becoming increasingly important to understand mechanisms of …

The immune system comprises diverse specialized cell types that cooperate to defend the
host against a wide range of pathogenic threats. Recent advancements in single-cell and …

Understanding the role of the tumor microenvironment (TME) in lung cancer is critical to
improving patient outcomes. We identified four histology-independent archetype TMEs in …

PARTNER is a prospective, phase II-III, randomised controlled clinical trial, which recruited
patients with Triple Negative Breast Cancer (TNBC) 1, 2, who were gBRCA wild type …

The spatial biology revolution promises deep insights into tissue organization, but deriving
this knowledge from diverse, complex data remains a major obstacle. Data-driven discovery …

Intratumoral tertiary lymphoid structures (TLSs) have been associated with improved
outcome in various cohorts of patients with cancer, reflecting their contribution to the …

Drought stress is one of the most important abiotic stresses which causes many yield losses
every year. This paper presents a comprehensive review of recent advances in international …

Breast cancer is the most common malignancy in women worldwide and a highly
heterogeneous disease. Four different subtypes are described that differ in the expression of …

Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

Adjuvant treatment after surgical resection usually plays an important role in delaying
disease recurrence. Immunotherapy displays encouraging results in increasing patients' …