[HTML][HTML] Spatial and Compositional Biomarkers in Tumor Microenvironment Predicts Clinical Outcomes in Triple-Negative Breast Cancer

H Mi, R Varadhan, AM Cimino-Mathews, LA Emens… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited
treatment options, which warrants identification of novel therapeutic targets. Deciphering …

Multiplex Digital Spatial Profiling in Breast Cancer Research: State-of-the-Art Technologies and Applications across the Translational Science Spectrum

M Rossi, DC Radisky - Cancers, 2024 - mdpi.com
Simple Summary Multiplex digital spatial profiling is a newly emerging approach for
investigating multiple RNA transcripts and proteins simultaneously in the context of intact …

Immunological Mechanisms behind Anti-PD-1/PD-L1 Immune Checkpoint Blockade: Intratumoral Reinvigoration or Systemic Induction?

Z Guo, J Yu, Z Chen, S Chen, L Wang - Biomedicines, 2024 - mdpi.com
Anti-PD-1/PD-L1 immune checkpoint blockade (ICB) has been widely used to treat many
types of cancer. It is well established that PD-L1 expressing cancer cells could directly inhibit …

[HTML][HTML] Multiplexed high-throughput immune cell imaging in patients with high-risk triple negative early breast cancer: Analysis from the International Breast Cancer …

S Rusakiewicz, S Tyekucheva, S Tissot-Renaud… - European Journal of …, 2024 - Elsevier
Background Triple-negative breast cancer (TNBC) is the most aggressive breast cancer
(BC) subtype, with dismal prognosis and limited option in advanced settings, yet stromal …

Immunologic Factors Associated with Differential Response to Neoadjuvant Chemoimmunotherapy in Triple-Negative Breast Cancer

RJ Seager, H Ko, S Pabla, MF Senosain… - Journal of Personalized …, 2024 - mdpi.com
Background: KEYNOTE-522 resulted in FDA approval of the immune checkpoint inhibitor
pembrolizumab in combination with neoadjuvant chemotherapy for patients with early-stage …

Magnetic Resonance Imaging in Breast Cancer Tissue In Vitro after PDT Therapy

D Bartusik-Aebisher, W Mytych, K Dynarowicz… - Diagnostics, 2024 - mdpi.com
Photodynamic therapy (PDT) is increasingly used in modern medicine. It has found
application in the treatment of breast cancer. The most common cancer among women is …

[HTML][HTML] Moving toward precision medicine to predict drug sensitivity in patients with metastatic breast cancer

M Bottosso, F Mosele, S Michiels, PH Cournède… - ESMO open, 2024 - Elsevier
Highlights•Precision medicine aims at personalizing cancer treatment through a deeper
understanding of tumor biology.•Genomics and new technological advances are shaping a …

2023 年度乳腺癌治疗新进展

吴云, 魏雨涵, 马飞 - 肿瘤综合治疗电子杂志, 2024 - jmcm2018.com
2023年度乳腺癌治疗新进展 Page 1 ● 年度盘点 ● 49 肿瘤综合治疗电子杂志2024 年第10 卷第
1 期 2023年度乳腺癌治疗新进展 吴云,魏雨涵,马飞(国家癌症中心/国家肿瘤临床医学研究中心 …

Predictors of Complete Pathological Response with Chemoimmunotherapy in Triple-Negative Breast Cancer: A Meta-Analysis

AM Roy, S Chintamaneni, S Alaklabi, H Awada… - Onco, 2023 - mdpi.com
Simple Summary We conducted a meta-analysis to understand the impact of adding
immunotherapy to chemotherapy in treating patients with triple-negative breast cancer …

Spatially tuneable multi-omics sequencing using light-driven combinatorial barcoding of molecules in tissues

G Battistoni, S Torres-Garcia, CY Sia, S Corriero… - bioRxiv, 2024 - biorxiv.org
Mapping the molecular identities and functions of cells within their spatial context is key to
understanding the complex interplay within and between tissue neighbourhoods. A wide …