[HTML][HTML] Pediatric acute myeloid leukemia—past, present, and future

D Reinhardt, E Antoniou, K Waack - Journal of clinical medicine, 2022 - mdpi.com
JCM | Free Full-Text | Pediatric Acute Myeloid Leukemia—Past, Present, and Future Next
Article in Journal Sexual Habits and Sexual Dysfunctions in a Sample of Patients with Psychotic …

[HTML][HTML] Regulatory mechanism of miR-20a-5p expression in Cancer

W Huang, X Wu, S Xiang, M Qiao, X Cen, X Pan… - Cell Death …, 2022 - nature.com
MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules encoded by
endogenous genes with a length of about 22 nucleotides. The dysregulation of miRNAs has …

The evolution of targeted therapy in pediatric AML: gemtuzumab ozogamicin, FLT3/IDH/BCL2 inhibitors, and other therapies

L Pommert, K Tarlock - Hematology, 2022 - ashpublications.org
Despite the maximum intensification of chemotherapy and the increased use of
hematopoietic stem cell transplantation (HCT) in pediatric patients with acute myeloid …

[HTML][HTML] The pediatric leukemia oncoprotein NUP98-KDM5A induces genomic instability that may facilitate malignant transformation

J Domingo-Reinés, R Montes, A Garcia-Moreno… - Cell Death & …, 2023 - nature.com
Abstract Pediatric Acute Myeloid Leukemia (AML) is a rare and heterogeneous disease
characterized by a high prevalence of gene fusions as driver mutations. Despite the …

[HTML][HTML] Significant improvement in survival of advanced stage childhood and young adolescent cancer in the Netherlands since the 1990s

M Schulpen, O Visser, AMJ Reedijk… - European Journal of …, 2021 - Elsevier
Background This is the first national study on trends in cancer survival and mortality for
children and young adolescents in the Netherlands including unique information on stage at …

Pediatric acute myeloid leukemia: Insight into genetic landscape and novel targeted approaches

N Tosic, I Marjanovic, J Lazic - Biochemical Pharmacology, 2023 - Elsevier
Acute myeloid leukemia (AML) is a very heterogeneous hematological malignancy that
accounts for approximately 20% of all pediatric leukemia cases. The outcome of pediatric …

[HTML][HTML] Diagnostic and therapeutic implications of long non-coding RNAs in Leukemia

V Gasic, T Karan-Djurasevic, D Pavlovic, B Zukic… - Life, 2022 - mdpi.com
Simple Summary Research on leukemia has often led to novel approaches in clinical
practice. Cytogenetical and molecular markers have been introduced in treatment protocols …

[HTML][HTML] Epigenomic machinery regulating pediatric AML: clonal expansion mechanisms, therapies, and future perspectives

U Chianese, C Papulino, W Megchelenbrink… - Seminars in Cancer …, 2023 - Elsevier
Acute myeloid leukemia (AML) is a heterogeneous disease with a genetic, epigenetic, and
transcriptional etiology mainly presenting somatic and germline abnormalities. AML …

[HTML][HTML] Molecular-targeted therapy of pediatric acute myeloid leukemia

P Obszański, A Kozłowska, J Wańcowiat… - Molecules, 2022 - mdpi.com
Acute myeloid leukemia (AML) accounts for approximately 15–20% of all childhood
leukemia cases. The overall survival of children with acute myeloid leukemia does not …

A prognostic model of seven immune genes to predict overall survival in childhood acute myeloid leukemia

Y Luo, Y Xu, X Li, X Shi, P Huang… - BioMed Research …, 2022 - Wiley Online Library
Background. Acute myeloid leukemia (AML) is one of the most common hematological
malignancies and accounts for about 20% of childhood leukemias. Currently …