Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
CRISPR technologies for genome, epigenome and transcriptome editing
Our ability to edit genomes lags behind our capacity to sequence them, but the growing
understanding of CRISPR biology and its application to genome, epigenome and …
understanding of CRISPR biology and its application to genome, epigenome and …
STING agonist-derived LNP-mRNA vaccine enhances protective immunity against SARS-CoV-2
Lipid nanoparticle (LNP)-mediated delivery of messenger RNA (mRNA) COVID-19 vaccines
has provided large-scale immune protection to the public. To elicit a robust immune …
has provided large-scale immune protection to the public. To elicit a robust immune …
Harnessing non-Watson–Crick's base pairing to enhance CRISPR effectors cleavage activities and enable gene editing in mammalian cells
Genomic DNA of the cyanophage S-2L virus is composed of 2-aminoadenine (Z), thymine
(T), guanine (G), and cytosine (C), forming the genetic alphabet ZTGC, which violates …
(T), guanine (G), and cytosine (C), forming the genetic alphabet ZTGC, which violates …
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1
X Xie, Q Lan, J Zhao, S Zhang, L Liu, Y Zhang… - … and Targeted Therapy, 2024 - nature.com
Respiratory disease caused by coronavirus infection remains a global health crisis.
Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available …
Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available …
Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection
Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely
unknown due to the biases of previous large-scale studies toward pro-viral host factors. To …
unknown due to the biases of previous large-scale studies toward pro-viral host factors. To …
A potential paradigm in CRISPR/Cas systems delivery: at the crossroad of microalgal gene editing and algal-mediated nanoparticles
S Feng, X Xie, J Liu, A Li, Q Wang, D Guo, S Li… - Journal of …, 2023 - Springer
Microalgae as the photosynthetic organisms offer enormous promise in a variety of
industries, such as the generation of high-value byproducts, biofuels, pharmaceuticals …
industries, such as the generation of high-value byproducts, biofuels, pharmaceuticals …
Lipid-coated mesoporous silica nanoparticles for anti-viral applications via delivery of CRISPR-Cas9 ribonucleoproteins
AE LaBauve, EA Saada, IKA Jones, R Mosesso… - Scientific reports, 2023 - nature.com
Emerging and re-emerging viral pathogens present a unique challenge for anti-viral
therapeutic development. Anti-viral approaches with high flexibility and rapid production …
therapeutic development. Anti-viral approaches with high flexibility and rapid production …
[HTML][HTML] Engineering LNPs with polysarcosine lipids for mRNA delivery
Since the approval of the lipid nanoparticles (LNP)-mRNA vaccines against the SARS-CoV-
2 virus, there has been an increased interest in the delivery of mRNA through LNPs …
2 virus, there has been an increased interest in the delivery of mRNA through LNPs …
Emerging Therapeutic Potential of Polyphenols from Geranium sanguineum L. in Viral Infections, Including SARS-CoV-2
The existing literature supports the anti-inflammatory, antioxidant, and antiviral capacities of
the polyphenol extracts derived from Geranium sanguineum L. These extracts exhibit …
the polyphenol extracts derived from Geranium sanguineum L. These extracts exhibit …