Alzheimer's disease: updated multi-targets therapeutics are in clinical and in progress
Z Sang, K Wang, J Dong, L Tang - European journal of medicinal chemistry, 2022 - Elsevier
Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …
over 30 million people globally. Currently, no effective treatment is available due to multiple …
A perspective on multi-target drugs for Alzheimer's disease
O Benek, J Korabecny, O Soukup - Trends in pharmacological sciences, 2020 - cell.com
Alzheimer's disease (AD) has a complex pathophysiology that includes aggregation of
pathological proteins, impaired neurotransmission, increased oxidative stress, or microglia …
pathological proteins, impaired neurotransmission, increased oxidative stress, or microglia …
[HTML][HTML] Tea and coffee polyphenols and their biological properties based on the latest in vitro investigations
P LIczbiński, B Bukowska - Industrial crops and products, 2022 - Elsevier
Tea and coffee contain numerous polyphenolic compounds that exhibit health-promoting
properties for humans, including antioxidant and neuroprotective properties, and can also …
properties for humans, including antioxidant and neuroprotective properties, and can also …
Alzheimer's disease pharmacotherapy in relation to cholinergic system involvement
GD Stanciu, A Luca, RN Rusu, V Bild… - Biomolecules, 2019 - mdpi.com
Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …
progressive form of dementia, associated with an ongoing decline of brain functioning. The …
New 3d multifunctional metal chelates of sulfonamide: spectral, vibrational, molecular modeling, DFT, medicinal and in silico studies
We are reporting a new synthetic design of sulfonamide entangled Schiff base ligands as H
2 L 1 and H 2 L 2 from 4-amino-N-(3-methyl-1, 2-oxazol-5-yl) benzene-1-sulfonamide and …
2 L 1 and H 2 L 2 from 4-amino-N-(3-methyl-1, 2-oxazol-5-yl) benzene-1-sulfonamide and …
Metal incorporated sulfonamides as promising multidrug targets: Combined enzyme inhibitory, antimicrobial, antioxidant and theoretical exploration
In this report, new sulfonamide based ligands (L 1)-(L 3) from 4-amino-N-(pyrimidin-2-yl)
benzene-1-sulfonamide are synthesized and branded on the basis of their physical …
benzene-1-sulfonamide are synthesized and branded on the basis of their physical …
Chemical composition, antioxidant and enzyme inhibitory properties of different extracts obtained from spent coffee ground and coffee silverskin
In a world where an eco-friendlier approach is becoming more and more necessary, it is
essential to reduce waste production and to reuse residues of the company's supply chain …
essential to reduce waste production and to reuse residues of the company's supply chain …
LC-MS/HRMS Analysis, Anti-Cancer, Anti-Enzymatic and Anti-Oxidant Effects of Boerhavia diffusa Extracts: A Potential Raw Material for Functional Applications
Boerhavia diffusa is a great tropical plant and is widely used for various traditional purposes.
In the present study, we examined the influence of solvents (dichloromethane, ethyl acetate …
In the present study, we examined the influence of solvents (dichloromethane, ethyl acetate …
Neuroprotective effects of cholinesterase inhibitors: current scenario in therapies for Alzheimer's disease and future perspectives
Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease
conceptualized as a continuous process, ranging from mild cognitive impairment (MCI), to …
conceptualized as a continuous process, ranging from mild cognitive impairment (MCI), to …
Some morpholine tethered novel aurones: Design, synthesis, biological, kinetic and molecular docking studies
Enzymes are the biological macromolecules that have emerged as an important drug target
as their upregulation/imbalance leads to various pathological conditions, such as …
as their upregulation/imbalance leads to various pathological conditions, such as …