Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …

Physical activity plays an essential role in maintaining a healthy body, yet it also provides
unique benefits for the vascular and cellular systems that sustain a healthy brain. While the …

Summary The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for
sporadic Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in …

Irisin, out-membrane part of fibronectin type III domain–containing 5 protein (FNDC5), was
activated by Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) …

Reduced expression of brain-derived neurotrophic factor (BDNF) has a crucial role in the
pathogenesis of Alzheimer's disease (AD), which is characterized with the formation of …

The beneficial effects of exercise on the brain are well known. However, the underlying
molecular mechanisms are much less well understood. Interestingly, myokines, hormones …

Most studies related to hemp are focused on Cannabidiol (CBD) and Tetrahydrocannabinol
(THC); however, up to 120 types of phytocannabinoids are present in hemp. Hemp leaves …

Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide.
Several findings suggest that correcting the dysregulated signaling pathways may offer a …

Alzheimer's disease (AD) is a neurodegenerative disorder associated with loss of memory
and cognitive abilities. Previous evidence suggested that exercise ameliorates learning and …

Neurotrophins (NTs) were first identified as target-derived survival factors for neurons of the
central and peripheral nervous system (PNS). They are known to control neural cell fate …