Simple Summary Breast cancer is the most common cancer affecting women under 40 years
of age worldwide, with an increasing number of cases diagnosed each year. Despite this …

Background: The contribution of BRCA germline mutational status to breast cancer patients'
prognosis is unclear. We aimed to systematically review and perform meta-analysis of the …

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and
Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants …

Background Olaparib is an oral poly (adenosine diphosphate–ribose) polymerase inhibitor
that has promising antitumor activity in patients with metastatic breast cancer and a germline …

Background Retrospective studies provide conflicting interpretations of the effect of inherited
genetic factors on the prognosis of patients with breast cancer. The primary aim of this study …

The International Agency for Research on Cancer (IARC) has recently reported a 66%
increase in the global number of cancer deaths since 1960. In the US alone, about one in …

BRCA1-and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is
characterized by an increased risk for female and male breast cancer, ovarian cancer …

Hereditary breast cancer is known for its strong tendency of inheritance. Most hereditary
breast cancers are related to BRCA1/BRCA2 pathogenic variants. The lifelong risk of breast …

Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and
environmental factors interact to contribute to its etiology. Remarkable progress has been …

The past few decades have witnessed a tremendous progress in understanding the biology
of cancer, which has led to more comprehensive approaches for global gene expression …