Transforming growth factor-beta (TGF-β) signaling is essential for the maintenance of the
normal structure and function of the aorta. It includes SMAD-dependent canonical pathways …

Thoracic aortic disease affects people of all ages and the majority of those aged< 60 years
have an underlying genetic cause. There is presently no effective medical therapy for …

Thoracic aortic aneurysms (TAA) are permanent and localized dilations of the aorta that
predispose patients to a life-threatening risk of aortic dissection or rupture. The identification …

Aortic aneurysms (AAs) are dilations of the aorta, that are often fatal upon rupture.
Diagnostic radiological techniques such as ultrasound (US), magnetic resonance imaging …

Heterozygous, loss of function mutations in positive regulators of the Transforming Growth
Factor-β (TGF-β) pathway cause hereditary forms of thoracic aortic aneurysm. It is unclear …

Thoracic aortic aneurysm is a potentially life-threatening disease with a strong genetic
contribution. Despite identification of multiple genes involved in aneurysm formation, little is …

The vascular extracellular matrix (ECM) is synthesized and secreted during embryogenesis
and facilitates the growth and remodeling of large vessels. Proper interactions between the …

Purpose To investigate the safety and efficacy of total endovascular repair for
thoracoabdominal aortic aneurysms (TAAAs) with fenestrated and branched stent-grafts …

Background: Thoracic aortopathy associates with extracellular matrix remodeling and
altered biomechanical properties. We sought to quantify the natural history of thoracic …

Ocular anterior segment dysgenesis (ASD) refers to a collection of developmental disorders
affecting the anterior structures of the eye. Although a number of genes have been …