Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

Genomic analysis of many nonmodel species has uncovered an incredible diversity of sex
chromosome systems, making it possible to empirically test the rich body of evolutionary …

It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters
with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 …

Abstract The Biomarkers of Nutrition for Development (BOND) project is designed to provide
evidence-based advice to anyone with an interest in the role of nutrition in health …

DNA modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)
are epigenetic marks known to affect global gene expression in mammals. Given their …

DNA methylation, an important type of epigenetic modification in humans, participates in
crucial cellular processes, such as embryonic development, X-inactivation, genomic …

DNA hypermethylation at the promoter of tumour-suppressor genes is tightly correlated with
their transcriptional repression and recognized as the hallmark of majority of cancers …

Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and
H3K27me3, histone modifications generally associated with transcriptionally active and …

Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

High-throughput sequencing, also known as next-generation sequencing (NGS), has
revolutionized genomic research. In recent years, NGS technology has steadily improved …