Biology and therapeutic targeting of vascular endothelial growth factor A

L Pérez-Gutiérrez, N Ferrara - Nature Reviews Molecular Cell Biology, 2023 - nature.com
The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …

[HTML][HTML] Angiogenic signaling pathways and anti-angiogenic therapy for cancer

ZL Liu, HH Chen, LL Zheng, LP Sun… - Signal transduction and …, 2023 - nature.com
Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

Absorption, distribution, metabolism, excretion and toxicity of microplastics in the human body and health implications

P Wu, S Lin, G Cao, J Wu, H Jin, C Wang… - Journal of Hazardous …, 2022 - Elsevier
Abstract Microplastics (MPs;< 5 mm) in the biosphere draws public concern about their
potential health impacts. Humans are potentially exposed to MPs via ingestion, inhalation …

[HTML][HTML] Vascular mechanobiology: homeostasis, adaptation, and disease

JD Humphrey, MA Schwartz - Annual review of biomedical …, 2021 - annualreviews.org
Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

Tumor targeting via EPR: Strategies to enhance patient responses

SK Golombek, JN May, B Theek, L Appold… - Advanced drug delivery …, 2018 - Elsevier
The tumor accumulation of nanomedicines relies on the enhanced permeability and
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …

[HTML][HTML] Oxidative stress in preeclampsia and placental diseases

R Aouache, L Biquard, D Vaiman… - International journal of …, 2018 - mdpi.com
Preeclampsia is a persistent hypertensive gestational disease characterized by high blood
pressure and proteinuria, which presents from the second trimester of pregnancy. At the …

[HTML][HTML] Contribution of angiogenesis to inflammation and cancer

D Aguilar-Cazares, R Chavez-Dominguez… - Frontiers in …, 2019 - frontiersin.org
During carcinogenesis, advanced tumors are surrounded by both stromal and immune cells,
which support tumor development. In addition, inflammation and angiogenesis are …

Recent trends and advances in fundus image analysis: A review

S Iqbal, TM Khan, K Naveed, SS Naqvi… - Computers in Biology and …, 2022 - Elsevier
Automated retinal image analysis holds prime significance in the accurate diagnosis of
various critical eye diseases that include diabetic retinopathy (DR), age-related macular …

[HTML][HTML] Impact of metabolic syndrome on neuroinflammation and the blood–brain barrier

P Van Dyken, B Lacoste - Frontiers in neuroscience, 2018 - frontiersin.org
Metabolic syndrome, which includes diabetes and obesity, is one of the most widespread
medical conditions. It induces systemic inflammation, causing far reaching effects on the …

[HTML][HTML] Vascular permeability in diseases

JL Wautier, MP Wautier - International Journal of Molecular Sciences, 2022 - mdpi.com
Vascular permeability is a selective mechanism that maintains the exchange between
vessels, tissues, and organs. The regulation was mostly studied during the nineteenth …