Organ or tissue dysfunction due to acute ischemia–reperfusion injury (IRI) is the leading
cause of death and disability worldwide. Acute IRI induces cell injury and death in a wide …

Despite decades of formidable exploration, multi-organ ischemia-reperfusion injury (IRI)
encountered, particularly amongst elderly patients with clinical scenarios, such as age …

Stroke is one of the leading causes of morbidity and mortality worldwide, and it is increasing
in prevalence. The limited therapeutic window and potential severe side effects prevent the …

The role of immunity in all stages of stroke is increasingly being recognized, from the
pathogenesis of risk factors to tissue repair, leading to the investigation of a range of …

Remote ischemic conditioning (RIC) represents an innovative cardioprotective method that
has been investigated in numerous clinical studies providing miscellaneous results. This …

Background Remote ischemic preconditioning (RIPC) has been shown to enhance the
tolerance of remote organs to cope with a subsequent ischemic event. We hypothesized that …

Despite great improvement during the past several decades, the management of stroke is
still far from satisfactory, which warrants alternative or adjunctive strategies. Remote …

The signal transducer and activator of transcription 3 (STAT3) signaling pathway has been
implicated in cell apoptosis and inflammatory processes. Ischemic preconditioning (IPC) and …

Ischemic conditioning is a form of endogenous protection induced by transient, subcritical
ischemia in a tissue. Organs with high sensitivity to ischemia, such as the heart, the brain …

We recently demonstrated that limb remote preconditioning (LRP) protects against focal
ischemia measured 2 days post-stroke. Here, we studied whether LRP provides long-term …