Immunomodulatory properties of vitamin D in the intestinal and respiratory systems

FN Hamza, S Daher, HMA Fakhoury, WB Grant… - Nutrients, 2023 - mdpi.com
Vitamin D plays a crucial role in modulating the innate immune response by interacting with
its intracellular receptor, VDR. In this review, we address vitamin D/VDR signaling and how it …

Epithelial pyroptosis in host defense

MJ Churchill, PS Mitchell, I Rauch - Journal of molecular biology, 2022 - Elsevier
Pyroptosis is a lytic form of cell death that is executed by a family of pore-forming proteins
called gasdermins (GSDMs). GSDMs are activated upon proteolysis by host proteases …

[HTML][HTML] The dynamic interplay between AMPK/NFκB signaling and NLRP3 is a new therapeutic target in inflammation: Emerging role of dapagliflozin in overcoming …

EE Abd El-Fattah, S Saber, AAE Mourad… - Biomedicine & …, 2022 - Elsevier
Acute lung injury (ALI) is one the most common causes of morbidity and mortality in critically
ill patients. In this study, we examined for first time the role of dapagliflozin (DPGZ) in …

Qingwenzhike Prescription Alleviates Acute Lung Injury Induced by LPS via Inhibiting TLR4/NF-kB Pathway and NLRP3 Inflammasome Activation

C Zhang, X Wang, C Wang, C He, Q Ma, J Li… - Frontiers in …, 2021 - frontiersin.org
Background: Acute lung injury (ALI) is characterized by dysfunction of the alveolar epithelial
membrane caused by acute inflammation and tissue injury. Qingwenzhike (QWZK) …

[HTML][HTML] Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury

X Qin, Y Zhou, C Jia, Z Chao, H Qin… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
The occurrence and development of acute lung injury (ALI) involve a variety of pathological
factors and complex mechanisms. How pulmonary cells communicate with each other and …

Unravelling the connection between COVID-19 and Alzheimer's disease: a comprehensive review

SR Shajahan, S Kumar, MDC Ramli - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Currently, there exists a limited comprehension regarding the correlation between COVID-
19 and Alzheimer's disease (AD). To elucidate the interrelationship and its impact on …

Fragment-Based Discovery of Azocyclic Alkyl Naphthalenesulfonamides as Keap1-Nrf2 Inhibitors for Acute Lung Injury Treatment

J Yan, Y Li, L Ding, R Hou, C Xing… - Journal of Medicinal …, 2023 - ACS Publications
Blocking the Kelch-like epichlorohydrin-related protein 1 (Keap1)-nuclear factor-erythroid 2
related factor 2 (Nrf2) pathway is a promising strategy to alleviate acute lung injury (ALI). A …

Design, synthesis fusidic acid derivatives alleviate acute lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway

Z Liu, X Huang, HY Guo, LW Zhang, YS Quan… - European Journal of …, 2023 - Elsevier
Acute lung injury (ALI) refers to a series of lung lesions resulting from multiple lung injuries,
even leading to morbidity and death, abundant previous reports have showed that anti …

[HTML][HTML] Tomatidine improves pulmonary inflammation in mice with acute lung injury

WC Huang, SJ Wu, YL Chen, CF Lin… - Mediators of …, 2021 - hindawi.com
Tomatidine, which is isolated from green tomato, can ameliorate inflammation and oxidative
stress in cells and animal experiments and has been shown to improve airway inflammation …

Ultrasound and microbubbles for targeted drug delivery to the lung endothelium in ARDS: cellular mechanisms and therapeutic opportunities

R Sanwal, K Joshi, M Ditmans, SSH Tsai, WL Lee - Biomedicines, 2021 - mdpi.com
Acute respiratory distress syndrome (ARDS) is characterized by increased permeability of
the alveolar–capillary membrane, a thin barrier composed of adjacent monolayers of …