Pyramidal neurons of the neocortex can be subdivided into two major groups: deep-(DL)
and upper-layer (UL) neurons. Here we report that the expression of the AT-rich DNA …

The molecular mechanisms underlying the axon arborization of mammalian neurons are
poorly understood but are critical for the establishment of functional neural circuits. We …

Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal
differentiation when expressed in neural progenitor cells. The mechanisms by which …

The cerebral cortex develops through the coordinated generation of dozens of neuronal
subtypes, but the mechanisms involved remain unclear. Here we show that mouse …

Reciprocal deletion and duplication of the 16p11. 2 region is the most common copy number
variation (CNV) associated with autism spectrum disorders. We generated cortical organoids …

During development of the mammalian cerebral cortex, radial glial cells (RGCs) generate
layer-specific subtypes of excitatory neurons in a defined temporal sequence, in which lower …

Multipotent neural progenitor cells (NPCs) undergo self-renewal while producing neurons,
astrocytes, and oligodendrocytes. These processes are controlled by multiple basic helix …

Neurons are among the most highly polarized cell types in the body, and the polarization of
axon and dendrites underlies the ability of neurons to integrate and transmit information in …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Under-connectivity between cerebral cortical association areas may underlie cognitive
deficits in neurodevelopmental disorders, including the 22q11. 2 deletion syndrome …