During development of the central nervous system, the transition from progenitor
maintenance to differentiation is directly triggered by a lengthening of the cell cycle that …

Pro-neural transcription factors and small molecules can induce the reprogramming of
fibroblasts into functional neurons; however, the immediate-early molecular events that …

A fundamental feature of neural development in vertebrates is that different cell types are
generated in a precise temporal sequence, first neurons, followed by oligodendrocytes and …

The positioning of neurons in the cerebral cortex is of crucial importance for its function as
highlighted by the severe consequences of migrational disorders in patients. Here we show …

Neurogenesis in the developing neocortex is a strictly regulated process of cell division and
differentiation. Here we report that a gradual retreat of canonical Wnt signaling in the cortex …

The architectonics of the mammalian brain arise from a remarkable range of directed cell
migrations, which orchestrate the emergence of cortical neuronal layers and pattern brain …

Cajal-Retzius (CR) cells are a transient cell population of the CNS that is critical for brain
development. In the neocortex, CR cells secrete reelin to instruct the radial migration of …

During development, pancreatic endocrine cells are specified within the pancreatic
epithelium. They subsequently delaminate out of the epithelium and cluster in the …

The formation of the neocortex relies on intracellular and extracellular signaling molecules
that are involved in the sequential steps of corticogenesis, ranging from the proliferation and …

During neocortical development, the neuroepithelial or neural precursor cells that commit to
neuronal fate need to delaminate and start migration toward the pial surface. However, the …