During development, several populations of progenitor cells in the dorsal telencephalon
generate a large variety of neurons which acquire distinct morphologies and physiological …

Carboxypeptidase E (CPE) or carboxypeptidase H was first discovered in 1982 as an
enkephalin-convertase that cleaved a C-terminal basic residue from enkephalin precursors …

Most neurons migrate with an elongated,“bipolar” morphology, extending a long leading
process that explores the environment. However, when immature projection neurons enter …

This review surveys immunocytochemical and histochemical markers of neuronal lineage for
application to tissue sections of fetal and neonatal brain. They determine maturation of …

The mechanisms by which proneural basic helix-loop-helix (bHLH) factors control
neurogenesis have been characterized, but it is not known how they specify neuronal cell …

Historically, the mammalian brain was thought to lack stem cells as no new neurons were
found to be made in adulthood. That dogma changed∼ 25 years ago with the identification …

The peculiar shape and disposition of Purkinje cell (PC) dendrites, planar and highly
branched, offers an optimal model to analyze cellular and molecular regulators for the …

The dentate gyrus (DG) of the hippocampus has a central role in learning and memory in
adult rodents. The DG is generated soon after birth, although new neurons continue to be …

Background The formation of the mammalian central nervous system requires the
establishment of complex neural circuits between a diverse array of neuronal subtypes …

Proneural genes encode evolutionarily conserved basic-helix–loop–helix transcription
factors. In Drosophila, proneural genes are required and sufficient to confer a neural identity …