Neuropathic pain is a common and debilitating modality of chronic pain induced by a lesion
or disease of the somatosensory nervous system. Albeit the elucidation of numerous …

Alzheimer's disease (AD) is a serious neurodegenerative disease characterized by memory
impairment, mental retardation, impaired motor balance, loss of self-care and even death …

Background Neuroinflammation in the peripheral nervous system has been linked to cancer
metastasis-induced bone pain. The stimulator of interferon genes (STING), an innate …

As a common clinical disease, neuropathic pain is difficult to be cured with drugs. The
occurrence and progression of pain is closely related to the response of spinal microglia. As …

Abstract Interferon-gamma (IFN-γ) signaling is necessary for the proinflammatory activation
of macrophages but IFN-γ-independent pathways, for which the initiating stimuli and …

Background This study aimed to investigate the potential mechanism of paeonol in the
treatment of neuropathic pain. Methods Relevant mechanisms were explored through …

Abstract Heat shock protein 22 (hsp22) plays a significant role in mitochondrial biogenesis
and redox balance. Moreover, it's well accepted that the impairment of mitochondrial …

Background Traumatic brain injury (TBI) is a significant worldwide public health concern that
necessitates attention. Apoptosis signal-regulating kinase 1 (ASK1), a key player in various …

Activated G-protein-coupled receptor 39 (GPR39) has been shown to attenuate
inflammation by interacting with sirtuin 1 (SIRT1) and peroxisome proliferator-activated …

Inflammatory pain is a type of pain caused by tissue damage associated with inflammation
and is characterized by hypersensitivity to pain and neuroinflammation in the spinal cord …