NO and its derivatives can have multiple effects, which impact on neuronal death in different
ways. High levels of NO induces energy depletion-induced necrosis, due to:(i) rapid …

Neuroinflammatory mediators play a crucial role in the pathophysiology of brain ischemia,
exerting either deleterious effects on the progression of tissue damage or beneficial roles …

Inflammatory processes have a fundamental role in the pathophysiology of stroke. A key
initial event is the rapid activation of resident immune cells, primarily microglia. This cell …

Nitric oxide (NO) is undoubtedly quite an important intercellular messenger in cerebral and
peripheral hemodynamics. This molecule, formed by constitutive isomers of NO synthase …

Ischaemic stroke and brain trauma are among the leading causes of mortality and long-term
disability in the western world. Enormous endeavours have been made to elucidate the …

Remote ischemic postconditioning (RIPoC) attenuates ischemia/reperfusion (I/R) injury in
the heart, lung and hind limb. RIPoC performed in the hind limb reduces brain injury …

Background and Purpose—Brain edema is detrimental in ischemic stroke and its treatment
options are limited. Kinins are proinflammatory peptides that are released during tissue …

Ischemic stroke is caused when blood flow to the brain is hampered, leading to instant
deficiency of nutrients and oxygen required for normal brain functioning. Reperfusion can …

Hematogenous recruitment of monocytes and macrophages has traditionally been viewed
as a harmful process causing exacerbation of brain injury after stroke. However, emerging …

Asiaticoside (AS) is isolated from Centella asiatica (L.) which has been using for a long time
as a memory enhancing drug in India. This study was to investigate the effects of AS on …