Opioids: a review of pharmacokinetics and pharmacodynamics in neonates, infants, and children

JC Thigpen, BL Odle, S Harirforoosh - European Journal of Drug …, 2019 - Springer
Pain management in the pediatric population is complex for many reasons. Mild pain is
usually managed quite well with oral acetaminophen or ibuprofen. Situations involving more …

Respiratory care for the ventilated neonate

G Rocha, P Soares, A Gonçalves… - Canadian respiratory …, 2018 - Wiley Online Library
Invasive ventilation is often necessary for the treatment of newborn infants with respiratory
insufficiency. The neonatal patient has unique physiological characteristics such as small …

[HTML][HTML] Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial

C Hartley, F Moultrie, A Hoskin, G Green, V Monk… - The Lancet, 2018 - thelancet.com
Background Infant pain has immediate and long-term effects but is undertreated because of
a paucity of evidence-based analgesics. Although morphine is often used to sedate …

[HTML][HTML] Advances in the management of acute postsurgical pain: a review

A Paladini, N Rawal, MC Martinez, M Trifa, A Montero… - Cureus, 2023 - ncbi.nlm.nih.gov
Despite the millions of surgeries performed every year around the world, postoperative pain
remains prevalent and is often addressed with inadequate or suboptimal treatments …

Analgesics and sedatives in critically ill newborns and infants: the impact on long‐term neurodevelopment

RM Schiller, K Allegaert, M Hunfeld… - The Journal of …, 2018 - Wiley Online Library
Inadequate pain and/or stress management in preterm‐and term‐born infants has been
associated with increased morbidity and even mortality. However, exposure to …

Considerations for neonatal and pediatric pain management

P Shah, A Siu - American Journal of Health-System Pharmacy, 2019 - academic.oup.com
Purpose Current literature and clinical practice guidelines on pediatric pain management
are reviewed. Summary Acute pain is commonly present in neonatal and pediatric patients …

Pharmacological data science perspective on fatal incidents of morphine treatment

Y Noufal, D Kringel, SW Toennes, R Dudziak… - Pharmacology & …, 2023 - Elsevier
Morphine prescribed for analgesia has caused drug-related deaths at an estimated
incidence of 0.3% to 4%. Morphine has pharmacological properties that make it particularly …

Metabolomics in pharmacology-a delve into the novel field of pharmacometabolomics

M Mussap, C Loddo, C Fanni… - Expert review of clinical …, 2020 - Taylor & Francis
Introduction: Pharmacometabolomics is an emerging science pursuing the application of
precision medicine. Combining both genetic and environmental factors, the so-called …

Premedication with neuromuscular blockade and sedation during neonatal intubation is associated with fewer adverse events

Y Ozawa, A Ades, EE Foglia, S DeMeo, J Barry… - Journal of …, 2019 - nature.com
Objective To determine the impact of premedication for tracheal intubation (TI) on adverse TI
associated events, severe oxygen desaturations, and first attempt success Study design …

Dexmedetomidine sedation in children

M Tervonen - 2024 - oulurepo.oulu.fi
Medical care often causes pain and anxiety in children. Providing procedural sedation and
analgesia has increasingly been implemented in pediatric healthcare, also during minor …