Dual‐Programmable Semiconducting Polymer NanoPROTACs for Deep‐Tissue Sonodynamic‐Ferroptosis Activatable Immunotherapy
Proteolysis‐targeting chimeras (PROTACs) can provide promising opportunities for cancer
treatment, while precise regulation of their activities remains challenging to achieve effective …
treatment, while precise regulation of their activities remains challenging to achieve effective …
Deep Insight into the Role of MIF in Spondyloarthritis
B Wu, A Nakamura - Current Rheumatology Reports, 2022 - Springer
Abstract Purpose of Review Pathological roles of macrophage migration inhibitory factor
(MIF) have recently been demonstrated in spondyloarthritis (SpA) preclinical models …
(MIF) have recently been demonstrated in spondyloarthritis (SpA) preclinical models …
[HTML][HTML] Cooperatively designed aptamer-PROTACs for spatioselective degradation of nucleocytoplasmic shuttling protein for enhanced combinational therapy
R Liu, Z Liu, M Chen, H Xing, P Zhang, J Zhang - Chemical Science, 2024 - pubs.rsc.org
Nucleocytoplasmic shuttling proteins (NSPs) have emerged as a promising class of
therapeutic targets for many diseases. However, most NSPs-based therapies largely rely on …
therapeutic targets for many diseases. However, most NSPs-based therapies largely rely on …
[HTML][HTML] Exploring the potential mechanism of emetine against coronavirus disease 2019 combined with lung adenocarcinoma: bioinformatics and molecular …
K Zhang, K Wang, C Zhang, X Teng, D Li, M Chen - BMC cancer, 2022 - Springer
Background Patients with lung adenocarcinoma (LUAD) may be more predisposed to
coronavirus disease 2019 (COVID-19) and have a poorer prognosis. Currently, there is still …
coronavirus disease 2019 (COVID-19) and have a poorer prognosis. Currently, there is still …
[HTML][HTML] A first glimpse into the M6A modification machinery of shrimp: Genomic features, expression patterns and potential roles in molting regulation
Y Lei, Q Zeng, G Tan, Z Yuan, N Zhang, J Liu… - Aquaculture …, 2023 - Elsevier
Abstract N6-methyladenosine (m 6 A) is the most abundant type of RNA modification in
eukaryotes, yet information on the m 6 A methylation enzymatic machinery of decapod …
eukaryotes, yet information on the m 6 A methylation enzymatic machinery of decapod …
[HTML][HTML] Characteristic roadmap of linker governs the rational design of PROTACs
Y Dong, T Ma, T Xu, Z Feng, Y Li, L Song, X Yao… - … Pharmaceutica Sinica B, 2024 - Elsevier
Proteolysis targeting chimera (PROTAC) technology represents a groundbreaking
development in drug discovery, leveraging the ubiquitin‒proteasome system to specifically …
development in drug discovery, leveraging the ubiquitin‒proteasome system to specifically …
From classic medicinal chemistry to state‐of‐the‐art interdisciplinary medicine: Recent advances in proteolysis‐targeting chimeras technology
X Zhao, Y Chen, H Su, L Zhang - Interdisciplinary Medicine, 2023 - Wiley Online Library
Proteolysis‐targeting chimeras (PROTACs) is a targeted protein degradation (TPD)
technique effected by hijacking the ubiquitin‐proteasome system (UPS) of the cells. A …
technique effected by hijacking the ubiquitin‐proteasome system (UPS) of the cells. A …
Recent insights of PROTAC developments in inflammation-mediated and autoimmune targets: A critical review
S Nagula, MS Galla, N Sharma, P Mishra - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
In account to the mounting evidences in the literature, pro-inflammatory mediators/targets
activate multiple signalling pathways to trigger the illness ultimately responsible for acute …
activate multiple signalling pathways to trigger the illness ultimately responsible for acute …
[HTML][HTML] Fluorescent probes and degraders of the sterol transport protein Aster-A
Our understanding of sterol transport proteins (STPs) has increased exponentially in the last
decades with advances in the cellular and structural biology of these important proteins …
decades with advances in the cellular and structural biology of these important proteins …
[HTML][HTML] Sustainability in drug discovery
E Wynendaele, C Furman, B Wielgomas… - Medicine in Drug …, 2021 - Elsevier
Due to the expanding and ageing world population, the importance and use of medicines is
expected to increase. However, this will lead to a greater impact on the ecosystem and our …
expected to increase. However, this will lead to a greater impact on the ecosystem and our …