Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of
iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion …

Misfolded alpha-synuclein (αSyn) aggregates are a hallmark event in Parkinson's disease
(PD) and other synucleinopathies. Recently, αSyn seed amplification assays (αSyn-SAAs) …

Abstract α-Synuclein (α-Syn) aggregation and amyloid formation is directly linked with
Parkinson's disease pathogenesis. However, the early events involved in this process …

Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …

Hormones are largely responsible for the integrated communication of several physiological
systems responsible for modulating cellular growth and development. Although the specific …

Parkinson's disease (PD) is the second most common neurodegenerative disease
characterized by motor dysfunction. Growing evidence has demonstrated that gut dysbiosis …

Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

Physical activity provides clinical benefit in Parkinson's disease (PD). Irisin is an exercise-
induced polypeptide secreted by skeletal muscle that crosses the blood–brain barrier and …

The gut microbiota (GM) plays an important role in the physiology and pathology of the host.
Microbiota communicate with different organs of the organism by synthesizing hormones …

Aberrant aggregation of the misfolded presynaptic protein, α-Synuclein (α-Syn) into Lewy
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …