SARS-CoV-2 infection causes spike-dependent fusion of infected cells with ACE2 positive
neighboring cells, generating multi-nuclear syncytia that are often associated with severe …

The COVID-19 pandemic has highlighted the need for human respiratory tract-based assay
platforms for efficient discovery and development of antivirals and disease-modulating …

COVID-19 emerged as a worldwide pandemic in early 2020, and while the rapid
development of safe and efficacious vaccines stands as an extraordinary achievement, the …

Abstract The National Center for Advancing Translational Sciences (NCATS) Assay
Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development …

The COVID-19 pandemic remains a serious public health problem globally. During winter
influenza seasons, more aggressive SARS-CoV-2 infections and fatalities have been …

The emergence of more transmissible or aggressive variants of SARS‐CoV‐2 requires the
development of antiviral medication that is quickly adjustable to evolving viral escape …

Endocytosis, or internalization through endosomes, is a major cell entry mechanism used by
respiratory viruses. Phosphoinositide 5-kinase (PIKfyve) is a critical enzyme for the synthesis …

The dynamics of SARS-CoV-2 infection in COVID-19 patients are highly variable, with a
subset of patients demonstrating prolonged virus shedding, which poses a significant …

Spike-mediated entry of SARS-CoV-2 into human airway epithelial cells is an attractive
therapeutic target for COVID-19. In addition to protein receptors, the SARS-CoV-2 spike (S) …

Background Elderly people are known to be vulnerable to virus infection. However, this has
not been appropriately tested in in vitro studies due to a lack of appropriate virus infection …