Venous thromboembolism affects 0.1% of the general population in the United States every
year, resulting in more than 50,000 deaths annually. Common predisposing conditions …

Abstract Context.—Factor V Leiden (FVL) is the most common heritable cause of venous
thrombosis. It is caused by a single nucleotide substitution resulting in an R506Q missense …

Activated protein C resistance assays can detect factor V Leiden with high accuracy,
depending on the method used. Factor Xa inhibitors such as rivaroxaban and direct …

This discussion considers several important hypercoagulable states that predispose patients
to venous, and in some instances, arterial thrombosis, focusing on activated protein C …

Objectives.—To present the current understanding of factor V Leiden and activated protein C
resistance, and to propose a laboratory testing algorithm. Data Sources.—Publications on …

BACKGROUND: Aprotinin has been shown to reduce blood transfusion in cardiac surgery.
Aprotinin inhibits activated protein C (APC). Patients with factor V (FV) Leiden have an …

A new automated method for screening defects in the Protein C Pathway (PCP) was
evaluated. The “PCP test” is based on a phospholipid-rich Russells viper venom reagent …

Background The most common cause of activated protein C (aPC) resistance is a missense
substitution (Arg506Gln), known as Factor V Leiden (FVL). Due to its low cost, many …

Clotting-based activated protein C (APC) assays have limitations when testing patients on
oral anticoagulant (OA) therapy or with a lupus anticoagulant (LA). Predilution in factor V …

Venous thromboembolism results in more than 50,000 deaths annually in the United States.
There are many predisposing conditions to thrombosis that are acquired, such as trauma …