The transcription factor CREB is best known for its involvement in learning and memory.
However, emerging evidence suggests that CREB activity has very different roles …

Abstract The NF-κB/REL family of transcription factors pivotally control the inflammatory and
immune responses, as well as other genetic programmes that are central to cell growth and …

NETosis, the process wherein neutrophils release highly decondensed chromatin called
neutrophil extracellular traps (NETs), has gained much attention as an alternative means of …

T cell development is orchestrated by transcription factors that regulate the expression of
genes initially buried within inaccessible chromatin, but the transcription factors that …

Macrophages participate in both the amplification of inflammation at the time of injury and
downregulation of the inflammatory response to avoid excess tissue damage. These …

In recent years, the number and types of known functional noncoding RNAs have increased
considerably. A subset of both short-and long-sized species are known to be involved in the …

Histone acetylation and deacetylation in the yeast Saccharomyces cerevisiae occur by
targeting acetyltransferase and deacetylase enzymes to gene promoters and, in an …

Thirty years ago, our conception of chromatin structure underwent a total metamorphosis as
the nucleosome era began. In Kurosawa's classic movie'Rashomon'(1951), each participant …

PARP-1 is the most abundantly expressed member of a family of proteins that catalyze the
transfer of ADP-ribose units from NAD+ to target proteins. Herein, we describe previously …

Histone acetyltransferases and deacetylases with specificities for different sites of
acetylation affect common chromatin regions. This could generate unique patterns of …