Heavy metal exist naturally in environment, but due to human and some natural activities
they have been entered to water bodies, air and soil and have become one of the major …

Zinc fingers (ZFs) are among the most structurally diverse protein domains. They interact
with nucleic acids, other proteins and lipids to facilitate a multitude of biological processes …

Human exposure to highly nickel-polluted environments, such as those associated with
nickel refining, electroplating, and welding, has the potential to produce a variety of …

The emergence of a nucleosome-based chromatin structure accompanied the evolutionary
transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the …

Although carcinogenic metals have been known to disrupt a wide range of cellular
processes the precise mechanism by which they exert their carcinogenic effects is not …

This review discusses the modes of coordination of oligopeptides by Cu (II) and Ni (II).
Special attention is given to two general classes of peptides. The first part of the review …

Several metals have been found to be carcinogenic to humans and/or animals (Tables 1
and 2). However, the underlying mechanisms remain unclear. It is believed that neoplastic …

DNA methylation and histone modification promote changes in chromatin structure that may
affect gene expression in a heritable manner without directly altering the genome. As such …

Nickel is a widely distributed metal that is industrially applied in many forms. Accumulated
epidemiological evidence confirms that exposures to nickel compounds are associated with …

The metal ions carcinogenic to humans are As, Be, Cd, Cr and Ni, and the candidates also
include Co, Cu, Fe and Pt. A range of molecular mechanisms was proposed for these …