Synapses are functionally distinct neuronal compartments that are critical for brain function,
with synaptic dysfunction being an early pathological feature in aging and disease. Given …

Neuronal survival requires continuous lysosomal turnover of cellular constituents delivered
by autophagy and endocytosis. Primary lysosomal dysfunction in inherited congenital …

This study aims to elucidate the processes underlying neuroprotection of kaempferol in
models of rotenone-induced acute toxicity. We demonstrate that kaempferol, but not …

Background Vitamin D deficiency is widespread in the world including the vulnerable group
of pregnant women. Vitamin D deficiency during pregnancy is hypothesized to contribute to …

We aimed to investigate mitochondrial function, biogenesis and autophagy in the brain of
type 2 diabetes (T2D) and Alzheimer's disease (AD) mice. Isolated brain mitochondria and …

Autophagy, the cellular process responsible for degradation and recycling of cytoplasmic
components through the autophagosomal–lysosomal pathway, is fundamental for neuronal …

Neonatology is a new field of medical practice, having come into its own in the 1960s. As the
practice has evolved, infants who were previously destined to die now survive, yet their …

Previously, we reported that RTP801, a stress regulated protein, is induced in multiple
cellular models of Parkinson's disease (PD), in an animal model of PD and in dopaminergic …

As neurons age, their survival depends on eliminating a growing burden of damaged,
potentially toxic proteins and organelles—a capability that declines owing to aging and …

Neuroepithelial cells undergoing differentiation efficiently remodel their cytoskeleton and
shape in an energy-consuming process. The capacity of autophagy to recycle cellular …