Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

Alzheimer's disease (AD) is the most common form of dementia worldwide, with a complex,
poorly understood pathogenesis. Cerebral atrophy, amyloid-β (Aβ) plaques, and …

Cellular Ca 2+ homeostasis is maintained through the integrated and coordinated function
of Ca 2+ transport molecules, Ca 2+ buffers and sensors. These molecules are associated …

The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated
through a vast network of biochemical pathways. This requires the regulated control of …

Neurons are known to rely on autophagy for removal of defective proteins or organelles to
maintain synaptic neurotransmission and counteract neurodegeneration. In spite of its …

S100 proteins are calcium-binding proteins that regulate several processes associated with
Alzheimer's disease (AD) but whose contribution and direct involvement in disease …

Pesticides are widely-used chemicals commonly applied in agriculture for the protection of
crops from pests. Depending on the class of pesticides, the specific substances may have a …

Vitamin D deficiency has been linked to many human diseases such as Alzheimer's disease
(AD), Parkinson's disease (PD), multiple sclerosis (MS), hypertension and cardiovascular …

The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …

One of the most critical pathological features of Alzheimer's disease (AD) is the
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …