Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …

Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation,
mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced …

The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly
with the aging of the population. Numerous epidemiological data suggest that there is a …

Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …

The ongoing obesity pandemic generates a constant need to develop new therapeutic
strategies to restore the energy balance. Therefore, the concept of activating brown adipose …

Obesity, a metabolic disorder, is becoming a worldwide epidemic that predominantly
increases the risk for various diseases including metabolic inflammation, insulin resistance …

Obesity and type 2 diabetes (T2D) are growing health challenges with unmet treatment
needs. Traf2-and NCK-interacting protein kinase (TNIK) is a recently identified obesity-and …

Diseases originating from altered energy homeostasis including obesity, and type 2
diabetes are rapidly increasing worldwide. Research in the last few decades on animal …

The liver is the central metabolic organ of the body, regulating energy and lipid metabolism,
while also having potent immunological functions. Overwhelming the metabolic capacity of …