Myofibroblasts have characteristics of fibroblasts and smooth muscle cells: they produce
extracellular matrix and are able to contract. In so doing, they can contribute to tissue …

The extracellular matrix (ECM) is a living network of proteins that maintains the structural
integrity of the myocardium and allows the transmission of electrical and mechanical forces …

Despite advances in treatment of patients who suffer from ischemic heart disease, morbidity
related to myocardial infarction is increasing in Western societies. Acute and chronic …

Classical therapy of heart failure is based on treatment of its pre-disposing/triggering factors
and of the neurohumoral activation secondary to the deterioration of cardiac function. A new …

Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death
(necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and …

PF-1355 is an oral myeloperoxidase (MPO) inhibitor that successfully decreased elevated
MPO activity in mouse myocardial infarction models. Short duration PF-1355 treatment for 7 …

The spectrum of the cardiac complications of arterial hypertension includes heart failure
(HF), sudden death, and cardiac dysrhythmias, as well as the exacerbation of coincidental …

Adverse cardiac remodelling is a major cause of morbidity and mortality following acute
myocardial infarction (MI). Mechanical and neurohumoral factors involved in structural and …

Despite considerable therapeutic advances, heart failure remains a medical and
socioeconomic problem. Thus, there is a compelling need for new drugs that could improve …

Objectives: The aim of this study was to investigate whether nebivolol has added effects on
left ventricular (LV) dysfunction and remodeling early after myocardial infarction (MI) beyond …