Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …

Ferroptosis, a type of regulated cell death driven by iron-dependent phospholipid
peroxidation, has captured much attention in the field of nanomedicine since it was coined in …

Introduction Cuproptosis and ferroptosis are the two newly defined metal-related regulated
cell death. However, the crosstalk between cuproptosis and ferroptosis is obscure. Materials …

Activating the strong immune system is a key initiative to counteract dormant tumors and
prevent recurrence. Herein, self‐destructive and multienzymatically active copper‐quinone …

Because of their intrinsic physiochemical and biological properties together with essential
role in living organism, copper (Cu) and Cu-based nanomaterials have garnered …

Both hydrogen (H2) and copper ions (Cu+) can be used as anti‐cancer treatments.
However, the continuous generation of H2 molecules and Cu+ in specific sites of tumors is …

Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …

The extracellular matrix (ECM) in the tumor microenvironment (TME) and upregulated
immune checkpoints (ICs) on antitumor immune cells impede the infiltration and killing effect …

Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …