Activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase
(cGAS)-stimulator of interferon genes (STING) pathway has great potential to promote …

Background: Widespread protein aggregation occurs in the living system under stress or
during aging, owing to disturbance of endoplasmic reticulum (ER) proteostasis. Many …

Hepatocellular carcinoma (HCC) resistant to both chemotherapy and immunotherapy is
among the deadliest malignancies. Doxorubicin widely used in transarterial chemotherapy …

Abstract N, N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally
used for ritual and therapeutic purposes across several South American countries. Here, we …

Abstract Sigma‐1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via
nuclear factor erythroid 2‐related factor 2 (NRF2), which plays a vital role in ferroptosis …

Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants,
Banisteriopsis caapi and Psychotria viridis. It contains the psychedelic 5-HT 2A and sigma-1 …

Ferroptosis is a novel form of cell death, which is characterized by accumulation of reactive
oxygen species (ROS). Sigma 1 receptor (S1R) has been suggested to function in oxidative …

In order to make the drug specifically aggregate at the tumor site, we had developed a
targeted drug delivery system based on pH responsive mesoporous silica nanoparticles …

Objective Adjunctive fenfluramine hydrochloride, classically described as acting
pharmacologically through a serotonergic mechanism, has demonstrated a unique and …

Dravet syndrome (DS) is a genetic encephalopathy that is characterized by severe seizures
and prominent co-morbidities (eg, physical, intellectual disabilities). More than 85% of the …