Emerging therapeutic options for follicular-derived thyroid cancer in the era of immunotherapy

N Turner, S Hamidi, R Ouni, R Rico… - Frontiers in …, 2024 - frontiersin.org
Although most follicular-derived thyroid cancers are well differentiated and have an overall
excellent prognosis following treatment with surgery and radioiodine, management of …

New horizons: emerging therapies and targets in thyroid cancer

MD Ringel - The Journal of Clinical Endocrinology & …, 2021 - academic.oup.com
The treatment of patients with progressive metastatic follicular cell-derived and medullary
thyroid cancers that do not respond to standard therapeutic modalities presents a …

The effects of Epigallocatechin-3-gallate and Dabrafenib combination on apoptosis and the genes involved in epigenetic events in anaplastic thyroid cancer cells

N Birden, N Selvi Gunel, NP Ozates, B Goker Bagca… - Medical Oncology, 2022 - Springer
Anaplastic thyroid cancer cases with poor prognosis are associated with epigenetic
modifications such as abnormal DNA methylation. Epigallocathesin-3-gallate (EGCG) is a …

A novel prognostic model for papillary thyroid cancer based on epithelial–mesenchymal transition‐related genes

R Liu, Z Cao, M Pan, M Wu, X Li, H Yuan… - Cancer …, 2022 - Wiley Online Library
Background The frequent incidence of postsurgical recurrence issues in papillary thyroid
cancer (PTC) patients is a primary concern considering the low cancer‐related mortality …

[HTML][HTML] Case report: Complete response of an anaplastic thyroid carcinoma patient with NRAS Q61R/BRAF D594N mutations to the triplet of dabrafenib, trametinib …

L Gui, Y Zhu, X Li, X He, T Ma, Y Cai, S Liu - Frontiers in Immunology, 2023 - frontiersin.org
Anaplastic thyroid carcinoma, BRAF non-V600, NRAS, combination immunotherapy and
targeted therapy, case report. Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid …

[HTML][HTML] Detection of the BRAFV600E Mutation in Circulating Free Nucleic Acids as a Biomarker of Thyroid Cancer: A Review

E Niedziela, Ł Niedziela, A Kowalska… - Journal of Clinical …, 2024 - mdpi.com
Background: Liquid biopsy is a method that could potentially improve the management of
thyroid cancer (TC) by enabling the detection of circulating tumor DNA and RNA (ctDNA …

Advances in pharmacotherapy for advanced thyroid cancer of follicular origin (PTC, FTC). New approved drugs and future therapies

G Elia, SM Ferrari, F Ragusa, SR Paparo… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The most common altered signaling found in aggressive iodine-refractory
thyroid cancers derived from follicular cells (RAI-TC) are RTK, MAPK, PI3K, WNT, BRAF …

[HTML][HTML] Kinase inhibitors in thyroid cancers

V Sukrithan, P Jain, MH Shah, B Konda - Endocrine Oncology, 2023 - eo.bioscientifica.com
Objective The treatment landscape for thyroid cancers has changed rapidly with the
availability of kinase inhibitors against VEGFR, BRAF, MEK, NTRK, and RET. We provide an …

Real-life utility of five-gene panel test in preoperative thyroid fine-needle aspiration biopsy: A large cohort of 740 patients study

J Tang, J Ma, X Xi, L Wang, H Li, S Huo, B Zhang - Endocrine, 2023 - Springer
Purpose Fine-needle aspiration (FNA) biopsy is an effective method to discriminate
malignant thyroid nodules but reaches indeterminate results in approximately 30% of cases …

[HTML][HTML] V600EBRAF Inhibition Induces Cytoprotective Autophagy through AMPK in Thyroid Cancer Cells

E Jiménez-Mora, B Gallego, S Díaz-Gago… - International Journal of …, 2021 - mdpi.com
The dysregulation of autophagy is important in the development of many cancers, including
thyroid cancer, where V600EBRAF is a main oncogene. Here, we analyse the effect of …