Activation of immune signals during organ transplantation

Q Li, P Lan - Signal transduction and targeted therapy, 2023 - nature.com
The activation of host's innate and adaptive immune systems can lead to acute and chronic
graft rejection, which seriously impacts graft survival. Thus, it is particularly significant to …

Role of neutrophils in different stages of atherosclerosis

X Zhang, Z Kang, D Yin, J Gao - Innate Immunity, 2023 - journals.sagepub.com
Neutrophils constitute the first line of defense in human immunity and can be attracted to
inflamed and infected sites by various chemokines. As essential players in immune …

Calprotectin, an emerging biomarker of interest in COVID-19: a systematic review and meta-analysis

R Udeh, S Advani, LG de Guadiana Romualdo… - Journal of clinical …, 2021 - mdpi.com
COVID-19 has been shown to present with varied clinical course, necessitating a need for
more specific diagnostic tools that could identify severe cases and predict outcomes during …

Neutrophils in cardiovascular disease: warmongers, peacemakers, or both?

G Sreejit, J Johnson, RM Jaggers… - Cardiovascular …, 2022 - academic.oup.com
Neutrophils, the most abundant of all leucocytes and the first cells to arrive at the sites of
sterile inflammation/injury act as a double-edged sword. On one hand, they inflict a …

Emerging roles of neutrophil-borne S100A8/A9 in cardiovascular inflammation

G Sreejit, AA Latif, AJ Murphy, PR Nagareddy - Pharmacological research, 2020 - Elsevier
Elevated neutrophil count is associated with higher risk of major adverse cardiac events
including myocardial infarction and early development of heart failure. Neutrophils …

Roles of S100A8, S100A9 and S100A12 in infection, inflammation and immunity

P Xia, X Ji, L Yan, S Lian, Z Chen, Y Luo - Immunology, 2024 - Wiley Online Library
S100 proteins are small proteins that are only expressed in vertebrates. They are widely
expressed in many different cell types and are involved in the regulation of calcium …

The role of gut-brain axis in a rotenone-induced rat model of Parkinson's disease

JCC Dos Santos, CSM Rebouças, LF Oliveira… - Neurobiology of …, 2023 - Elsevier
Parkinson's disease (PD) is a widespread neurodegenerative condition affecting millions
globally. This investigation centered on the gut-brain axis in a rotenone-induced PD rat …

Oxidative stress in neutrophils: implications for diabetic cardiovascular complications

J Johnson, RM Jaggers, S Gopalkrishna… - Antioxidants & redox …, 2022 - liebertpub.com
Significance: Neutrophil behavior and function are altered by hyperglycemia associated with
diabetes. Aberrant activation by hyperglycemia causes neutrophils to respond with …

S100A11 promotes focal adhesion disassembly via myosin II-driven contractility and Piezo1-mediated Ca2+ entry

TO Mohammed, YR Lin, L Akter… - Journal of Cell …, 2024 - journals.biologists.com
ABSTRACT S100A11 is a small Ca2+-activatable protein known to localize along stress
fibers (SFs). Analyzing S100A11 localization in HeLa and U2OS cells further revealed …

Molecular actors of inflammation and their signaling pathways: mechanistic insights from zebrafish

J Leiba, R Özbilgiç, L Hernández, M Demou, G Lutfalla… - Biology, 2023 - mdpi.com
Simple Summary Inflammation is a central part of the body's response to harm that can be
elicited by microbes, environmental factors, or internal injuries. This complex physiological …