The SOX proteins belong to the superfamily of transcription factors (TFs) that display
properties of both classical TFs and architectural components of chromatin. Since the …

The neuroendocrine hypothalamus is composed of the tuberal and anterodorsal
hypothalamus, together with the median eminence/neurohypophysis. It centrally governs …

The development of the anterior pituitary gland occurs in distinct sequential developmental
steps, leading to the formation of a complex organ containing five different cell types …

The CreER/LoxP system is widely accepted to track neural lineages and study gene
functions upon tamoxifen (TAM) administration. We have observed that prenatal TAM …

The quest for eternal youth and immortality is as old as humankind. Ageing is an inevitable
physiological process accompanied by many functional declines that are driving factors for …

The small freshwater cnidarian polyp Hydra vulgaris uses adult stem cells (interstitial stem
cells) to continually replace neurons throughout its life. This feature, combined with the …

SOX3 is a transcription factor expressed within the developing and adult nervous system
where it mostly functions to help maintain neural precursors. Sox3 is also expressed in other …

Recent evidence suggests the aging process is accelerated by HIV. Degradation of white
matter (WM) has been independently associated with HIV and healthy aging. Thus, WM may …

The X and Y chromosomes play important roles outside of human reproduction; namely,
their potential contribution to human sex biases in physiology and disease. While sex biases …

The hippocampus is a brain area central for cognition. Mutations in the human SOX2
transcription factor cause neurodevelopmental defects, leading to intellectual disability and …