Pseudomonas aeruginosa is a ubiquitous, motile, gram-negative bacterium that has been
recently identified as a multi-drug resistant pathogen in critical need of novel therapeutics. Of …

Highlights•P. aeruginosa is opportunistic pathogen with an environmental origin.•P.
aeruginosa presents low susceptibility to currently used antibiotics.•P. aeruginosa displays a …

Antibiotic resistance poses a global health threat, but the within-host drivers of resistance
remain poorly understood. Pathogen populations are often assumed to be clonal within …

Driven in part by its metabolic versatility, high intrinsic antibiotic resistance, and a large
repertoire of virulence factors, Pseudomonas aeruginosa is expertly adapted to thrive in a …

Our view of genome size in Archaea and Bacteria has remained skewed as the data has
been dominated by genomes of microorganisms that have been cultivated under laboratory …

Achromobacter species are increasingly being detected in patients with cystic fibrosis (CF),
and this emerging pathogen is associated with antibiotic resistance and more-severe …

Highlights•Pseudomonas aeruginosa in CF airways: paradigm of bacterial microevolution.•
Evolution within CF host triggers conversions of genotype and phenotype.•Severity of lung …

The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lungs of
patients with cystic fibrosis (CF). During infection the bacteria evolve and adapt to the lung …

Microbial interactions are increasingly recognized as an integral part of microbial
physiology. Cell–cell communication mediated by quorum sensing and metabolite …

Bacterial pathogens undergo remarkable adaptive change in response to the selective
forces they encounter during host colonization and infection. Studies performed over the …