Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …
[HTML][HTML] Role of miR-2392 in driving SARS-CoV-2 infection
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene
regulation that have a major impact on many diseases and provide an exciting avenue …
regulation that have a major impact on many diseases and provide an exciting avenue …
[HTML][HTML] System-wide transcriptome damage and tissue identity loss in COVID-19 patients
The molecular mechanisms underlying the clinical manifestations of coronavirus disease
2019 (COVID-19), and what distinguishes them from common seasonal influenza virus and …
2019 (COVID-19), and what distinguishes them from common seasonal influenza virus and …
[HTML][HTML] Targeted down regulation of core mitochondrial genes during SARS-CoV-2 infection
Defects in mitochondrial oxidative phosphorylation (OXPHOS) have been reported in COVID-
19 patients, but the timing and organs affected vary among reports. Here, we reveal the …
19 patients, but the timing and organs affected vary among reports. Here, we reveal the …
orfipy: a fast and flexible tool for extracting ORFs
U Singh, ES Wurtele - Bioinformatics, 2021 - academic.oup.com
Searching for open reading frames is a routine task and a critical step prior to annotating
protein coding regions in newly sequenced genomes or de novo transcriptome assemblies …
protein coding regions in newly sequenced genomes or de novo transcriptome assemblies …
[HTML][HTML] SARS-CoV-2 Orphan Gene ORF10 Contributes to More Severe COVID-19 Disease
The orphan gene of SARS-CoV-2, ORF10, is the least studied gene in the virus responsible
for the COVID-19 pandemic. Recent experimentation indicated ORF10 expression …
for the COVID-19 pandemic. Recent experimentation indicated ORF10 expression …
Foster thy young: enhanced prediction of orphan genes in assembled genomes
Proteins encoded by newly-emerged genes ('orphan genes') share no sequence similarity
with proteins in any other species. They provide organisms with a reservoir of genetic …
with proteins in any other species. They provide organisms with a reservoir of genetic …
Escherichia coli transcriptome assembly from a compendium of RNA-seq data sets
B Tjaden - RNA biology, 2023 - Taylor & Francis
Owing to the complexities of bacterial RNA biology, the transcriptomes of even the best
studied bacteria are not fully understood. To help elucidate the transcriptional landscape of …
studied bacteria are not fully understood. To help elucidate the transcriptional landscape of …
[HTML][HTML] SARS-CoV-2 mitochondrial metabolic and epigenomic reprogramming in COVID-19
JW Guarnieri, JA Haltom, YES Albrecht, T Lie… - Pharmacological …, 2024 - Elsevier
To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an
exhaustive survey of the cellular metabolic pathways modulated by SARS-CoV-2 infection …
exhaustive survey of the cellular metabolic pathways modulated by SARS-CoV-2 infection …
ARA: a flexible pipeline for automated exploration of NCBI SRA datasets
Background One of the most effective and useful methods to explore the content of
biological databases is searching with nucleotide or protein sequences as a query …
biological databases is searching with nucleotide or protein sequences as a query …