The Challenge of overcoming antibiotic resistance in carbapenem-resistant Gram-negative bacteria:“Attack on Titan”

G Mancuso, S De Gaetano, A Midiri, S Zummo… - Microorganisms, 2023 - mdpi.com
The global burden of bacterial resistance remains one of the most serious public health
concerns. Infections caused by multidrug-resistant (MDR) bacteria in critically ill patients …

[HTML][HTML] The prospective role of cefiderocol in the management of carbapenem-resistant Acinetobacter baumannii infections: review of the evidence

M Kollef, H Dupont, DE Greenberg, P Viale… - International Journal of …, 2023 - Elsevier
Carbapenem-resistant Acinetobacter baumannii (CRAB) has been classified by the World
Health Organization as being in the critical category of pathogens requiring urgent new …

Effectiveness of First-Line Therapy with Old and Novel Antibiotics in Ventilator-Associated Pneumonia Caused by Carbapenem-Resistant Acinetobacter baumannii: A …

L Dalfino, M Stufano, DF Bavaro, L Diella, A Belati… - Antibiotics, 2023 - mdpi.com
Evidence-based, standard antibiotic therapy for ventilator-associated pneumonia (VAP)
caused by carbapenem-resistant Acinetobacter baumannii (CRAB) is a relevant unmet …

Cefiderocol Versus Colistin for the Treatment of Carbapenem-Resistant Acinetobacter baumannii Complex Bloodstream Infections: A Retrospective, Propensity-Score …

DF Bavaro, R Papagni, A Belati, L Diella… - Infectious Diseases and …, 2023 - Springer
Introduction Bloodstream infections (BSI) caused by carbapenem-resistant Acinetobacter
baumannii (CRAB) are associated with high mortality with limited treatment. The aim of this …

Intravenous fosfomycin in combination regimens as a treatment option for difficult-to-treat infections due to multi-drug-resistant Gram-negative organisms: A real-life …

M Meschiari, M Faltoni, S Kaleci, G Tassoni… - International Journal of …, 2024 - Elsevier
Aim To investigate the efficacy of intravenous (IV) fosfomycin as combination therapy for
treatment of difficult-to-treat (DTT) acute and subacute infections with multi-drug-resistant …

Intravenous fosfomycin for treatment of severe infections caused by carbapenem-resistant Acinetobacter baumannii: a multicenter clinical experience

A Russo, SP Gullì, A D'Avino, C Borrazzo… - International Journal of …, 2024 - Elsevier
Background severe infections caused by carbapenem-resistant Acinetobacter baumannii
(CRAB) have been increasingly reported over the past few years. Many in vivo and in vitro …

Acinetobacter baumannii Bloodstream Infections in the COVID-19 Era: A Comparative Analysis between COVID-19 and Non-COVID-19 Critically Ill Patients

I Andrianopoulos, T Maniatopoulou, N Lagos… - Microorganisms, 2023 - mdpi.com
The coronavirus disease (COVID-19) pandemic increased the incidence of severe infections
caused by multidrug-resistant (MDR) pathogens among critically ill patients, such as …

Lights and Shadows of Sepsis Management: Challenges and Future Perspectives

A Russo, R Pallone, EM Trecarichi, C Torti - International Journal of …, 2023 - mdpi.com
The complex interaction between microorganisms, the host's immune response, and the
release of pro-and anti-inflammatory factors influence the evolution of sepsis. According to …

Antibiotic Treatment of Carbapenem-Resistant Acinetobacter baumannii Infections in View of the Newly Developed β-Lactams: A Narrative Review of the Existing …

F Serapide, M Guastalegname, SP Gullì, R Lionello… - Antibiotics, 2024 - mdpi.com
It is estimated that antimicrobial resistance (AMR) is responsible for nearly 5 million human
deaths worldwide each year and will reach 10 million by 2050. Carbapenem-resistant …

[HTML][HTML] Cefiderocol either in monotherapy or combination versus best available therapy in the treatment of carbapenem-resistant Acinetobacter baumannii infections …

L Onorato, I de Luca, C Monari, N Coppola - Journal of Infection, 2024 - Elsevier
Background The best treatment for carbapenem-resistant Acinetobacter baumannii (CRAB)
infections is still a matter of debate. Objectives To describe the outcomes of patients treated …