Importance Abnormalities of axonal excitability characterized by upregulation of persistent
sodium (Na+) conductances and reduced potassium (K+) currents have been reported in …

The motor unit comprises the anterior horn cell, its axon, and the muscle fibers that it
innervates. Although the true number of motor units is unknown, the number of motor units …

Background: While patients with amyotrophic lateral sclerosis (ALS) may complain of
fatigue, the underlying mechanisms appear complex, with dysfunction of central and …

We studied the upper (UMN) and lower motor neuron (LMN) innervations of 159 hands from
81 patients with amyotrophic lateral sclerosis (ALS). Eleven patients with various chronic …

The Neurophysiological Index (NI) consists of a mathematical derivation of three
standardised neurophysiological measurements. Since these measurements are part of …

Our objective was to evaluate the neurophysiological index (NI) as a biomarker for
amyotrophic lateral sclerosis (ALS) and to assess the validity of linear mixed effects models …

AIMS: To test the influence of caffeine on the lower and upper motor neuron excitability.
METHODS: In Experiment A, 18 healthy subjects received 200 mg of caffeine or placebo, in …

Objective The aim of the study was to assess the utility of a novel amyotrophic lateral
sclerosis (ALS) diagnostic index (ALSDI). Methods A prospective multicenter study was …

OBJECTIVE: Phrenic nerve motor amplitude (Diaphr Ampl) is predictive of hypoventilation in
amyotrophic lateral sclerosis (ALS). We aimed to evaluate its change over disease course …

Background Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative
disease. Pathologically, it is characterized by eosinophilic hyaline intranuclear inclusions in …