Click and bioorthogonal chemistry: the future of active targeting of nanoparticles for nanomedicines?
Over the years, click and bioorthogonal reactions have been the subject of considerable
research efforts. These high-performance chemical reactions have been developed to meet …
research efforts. These high-performance chemical reactions have been developed to meet …
Metabolic glycan labelling for cancer-targeted therapy
Metabolic glycoengineering with unnatural sugars provides a powerful tool to label cell
membranes with chemical tags for subsequent targeted conjugation of molecular cargos via …
membranes with chemical tags for subsequent targeted conjugation of molecular cargos via …
Metal–organic‐framework‐assisted in vivo bacterial metabolic labeling and precise antibacterial therapy
Bacterial infection is one of the most serious physiological conditions threatening human
health. There is an increasing demand for more effective bacterial diagnosis and treatment …
health. There is an increasing demand for more effective bacterial diagnosis and treatment …
[HTML][HTML] Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry
W Yi, P Xiao, X Liu, Z Zhao, X Sun, J Wang… - … and Targeted Therapy, 2022 - nature.com
Bioorthogonal chemistry reactions occur in physiological conditions without interfering with
normal physiological processes. Through metabolic engineering, bioorthogonal groups can …
normal physiological processes. Through metabolic engineering, bioorthogonal groups can …
T cell membrane mimicking nanoparticles with bioorthogonal targeting and immune recognition for enhanced photothermal therapy
Due to specific immune recognition receptors on the surface of T cells, their membranes are
promising mimic nanocarriers for delivering drugs to tumor lesions. However, this single …
promising mimic nanocarriers for delivering drugs to tumor lesions. However, this single …
Metabolic labeling and targeted modulation of dendritic cells
Targeted immunomodulation of dendritic cells (DCs) in vivo will enable manipulation of T-
cell priming and amplification of anticancer immune responses, but a general strategy has …
cell priming and amplification of anticancer immune responses, but a general strategy has …
Red/NIR‐Emissive Benzo[d]imidazole‐Cored AIEgens: Facile Molecular Design for Wavelength Extending and In Vivo Tumor Metabolic Imaging
Aggregation‐induced emission (AIE) luminogens (AIEgens) with red/near‐infrared (NIR)
emissions are appealing for applications in optoelectronics and biomedical engineering …
emissions are appealing for applications in optoelectronics and biomedical engineering …
Multifunctional silica nanoparticles as a promising theranostic platform for biomedical applications
Theranostic nanoplatforms represent an important tool in the diagnosis and therapy of many
major diseases, especially in the field of cancer theranostics, for which a myriad of …
major diseases, especially in the field of cancer theranostics, for which a myriad of …
[HTML][HTML] Therapeutic applications of pretargeting
M Verhoeven, Y Seimbille, SU Dalm - Pharmaceutics, 2019 - mdpi.com
Targeted therapies, such as radioimmunotherapy (RIT), present a promising treatment
option for the eradication of tumor lesions. RIT has shown promising results especially for …
option for the eradication of tumor lesions. RIT has shown promising results especially for …
[HTML][HTML] Tumor-penetrating peptide conjugated and doxorubicin loaded T1-T2 dual mode MRI contrast agents nanoparticles for tumor theranostics
L Gao, J Yu, Y Liu, J Zhou, L Sun, J Wang, J Zhu… - Theranostics, 2018 - ncbi.nlm.nih.gov
The conventional chemotherapeutics could not be traced in vivo and provide timely
feedback on the clinical effectiveness of drugs. Methods: In this study, a tumor-penetrating …
feedback on the clinical effectiveness of drugs. Methods: In this study, a tumor-penetrating …